Zhang L L, Lu Y H, Cheng X L, Liu M Y, Sun B R, Li C L
Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.
Zhonghua Nei Ke Za Zhi. 2016 Aug 1;55(8):599-603. doi: 10.3760/cma.j.issn.0578-1426.2016.08.006.
To evaluate vitamin D status in middle-aged subjects in Beijing and explore the correlation between serum 25-hydroxyvitamin D[25(OH)D] levels and dyslipidemia.
A total of 448 individuals over 40 years old were enrolled in the cross-sectional survey. The general information, blood biochemical and lipid profiles and serum 25(OH)D levels were collected. The subjects were either divided into two groups (the dyslipidemia group and the non-dyslipidemia group) based on the lipid levels, or four groups according to quartiles of 25(OH)D levels. The association between 25(OH)D levels and dyslipidemia risk was analyzed by a logistic regression analysis.
A total of 234 cases were in dyslipidemia group, which accounted for 52.23% of the subjects. The serum 25(OH)D levels were significantly lower in the dyslipidemia group than in the non-dyslipidemia group both in men and in women (all P<0.05). The median serum 25(OH)D level in the total subjects was 15.7 (12.2, 20.1)μg/L with 91.1% subjects of serum 25(OH)D level<30 μg/L. The proportion of subjects with dyslipidemia (high TC, high TG, high LDL-C, or low HDL-C) increased with the decrease of 25(OH)D level quartiles (P<0.05). After adjustment of confounding factors, the logistic regression analysis showed that subjects in the lowest 25(OH) D quartile group had 143% higher risks for dyslipidemia than those in the highest quartile group.
These findings indicate that 25(OH)D insufficiency is highly prevalent among middle-aged individuals and it may be associated with the risk of dyslipidemia.
评估北京中年人群的维生素D状况，并探讨血清25-羟维生素D[25(OH)D]水平与血脂异常之间的相关性。
共有448名40岁以上个体纳入横断面调查。收集一般信息、血液生化指标、血脂谱以及血清25(OH)D水平。根据血脂水平将受试者分为两组（血脂异常组和非血脂异常组），或根据25(OH)D水平的四分位数分为四组。通过逻辑回归分析25(OH)D水平与血脂异常风险之间的关联。
血脂异常组共234例，占受试者的52.23%。无论男性还是女性，血脂异常组的血清25(OH)D水平均显著低于非血脂异常组（均P<0.05）。全部受试者血清25(OH)D水平中位数为15.7(12.2, 20.1)μg/L，91.1%的受试者血清25(OH)D水平<30μg/L。血脂异常（高总胆固醇、高甘油三酯、高低密度脂蛋白胆固醇或低高密度脂蛋白胆固醇）受试者比例随25(OH)D水平四分位数降低而增加（P<0.05）。校正混杂因素后，逻辑回归分析显示，25(OH)D最低四分位数组的受试者发生血脂异常的风险比最高四分位数组高143%。
这些发现表明，25(OH)D不足在中年个体中非常普遍，且可能与血脂异常风险相关。
