Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Department of Health Management Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
J Nutr Sci Vitaminol (Tokyo). 2020;66(2):105-113. doi: 10.3177/jnsv.66.105.
Studies have shown that vitamin D status might be associated with dyslipidaemia, but results are conflicting and there might exist sex differences. The aim of our study was to explore the sex-specific association between vitamin D status and serum lipids and atherogenic index of plasma (AIP, a predictor for atherosclerosis) among Chinese middle-aged and elderly adults. A total of 4,021 middle-aged and elderly participants from a health management centre were included in this cross-sectional study. The individuals were classified into tertiles according to serum 25(OH)D. Linear and logistic regression models were used to estimate the association between vitamin D levels and serum lipids among the tertiles. The mean serum 25(OH)D level was 21.60 (16.60-27.20) ng/mL in all participants. After adjusting for potential confounders, a 10 ng/mL increase in 25(OH)D was associated with decreases of 1.156 mmol/L in triglycerides (TGs) and 0.068 in the AIP and an increase of 0.051 mmol/L in high-density lipoprotein cholesterol (HDL-C) in all subjects. In addition, 25(OH)D deficiency was associated with an increased prevalence of hypertriglyceridaemia (odds ratio (OR), 1.880; 95% confidence interval (CI), 1.351-2.615), hypoalphalipoproteinaemia/HDL (OR, 1.505; 95% CI, 1.146-1.977) and abnormal AIP (OR, 1.933; 95% CI, 1.474-2.534) in males, and 25(OH)D-deficient women had a 2.02-fold higher risk for hypoalphalipoproteinaemia/HDL than women with sufficient 25(OH)D levels (95% CI, 1.044-3.904; all p values <0.05). Vitamin D deficiency was positively associated with the prevalence of dyslipidaemia and abnormal AIP in the middle-aged and elderly Chinese population. And this association was stronger in men than in women.
研究表明，维生素 D 状态可能与血脂异常有关，但结果存在矛盾，并且可能存在性别差异。我们的研究目的是探讨中国中老年人维生素 D 状态与血清脂质和血浆致动脉粥样硬化指数（AIP，动脉粥样硬化的预测指标）之间的性别特异性关联。本横断面研究共纳入了来自健康管理中心的 4021 名中老年人。根据血清 25(OH)D 将个体分为三分位。线性和 logistic 回归模型用于估计维生素 D 水平与三分位血清脂质之间的关系。所有参与者的平均血清 25(OH)D 水平为 21.60（16.60-27.20）ng/mL。在校正潜在混杂因素后，25(OH)D 每增加 10ng/mL，总胆固醇（TC）降低 1.156mmol/L，AIP 降低 0.068，高密度脂蛋白胆固醇（HDL-C）升高 0.051mmol/L。此外，25(OH)D 缺乏与男性高甘油三酯血症（比值比（OR），1.880；95%置信区间（CI），1.351-2.615）、低α脂蛋白血症/HDL（OR，1.505；95%CI，1.146-1.977）和异常 AIP（OR，1.933；95%CI，1.474-2.534）的患病率增加相关，而 25(OH)D 缺乏的女性患低α脂蛋白血症/HDL 的风险是 25(OH)D 充足女性的 2.02 倍（95%CI，1.044-3.904；所有 p 值<0.05）。维生素 D 缺乏与中国中老年人群血脂异常和异常 AIP 的患病率呈正相关，且这种相关性在男性中强于女性。
