Brodsky Sergey V, Gruszecki Amy C, Fallon Kim, Pasquale-Styles Melissa A, Shaddy Sophia, Yildiz Vedat, Long Sarah K, MacDonell Michelle, Brideau Renee L, Keane Joanne, Allenby Patricia, Ivanov Iouri, Moore Stephen, Smith Stephen M, Sachak Taha, Ball Matthew, Yao Keluo, James Iyore, Muni Navin, Barth Rolf F
Department of Pathology, The Ohio State University, 333 W 10th Ave, Graves Hall, B078, Columbus, OH, 43210, USA.
American Forensics, LLC, Dallas, TX, USA.
Virchows Arch. 2016 Oct;469(4):451-8. doi: 10.1007/s00428-016-1994-x. Epub 2016 Aug 2.
With the widespread increase in the incidence of obesity, autopsies on severely and morbidly obese deceased have become common in the USA. Standard reference tables for organ weights provide little or no information on individuals with a body mass index greater than 35 kg/m(2). Although several recent reports have provided organ weights for small numbers of morbidly obese persons who died naturally from a variety of causes, these data may have been affected by comorbidities. Furthermore, they did not provide information relative to differences in organ weight based on gender, age, and race. The aim of the present study was to fill this void by developing reference tables for organ weights of severely and morbidly obese individuals. Our study was based on data from 802 forensic and medical autopsies, including 435 cases of death of natural and 367 of non-natural causes. Organ weights were compared between these groups, and reference ranges were generated. Significant variability was found in organ weights especially among deceased older than 40 years who died naturally, suggesting that comorbidities affect organ weight. Reference tables were compiled for organ weights and morphometric data based on gender, age, and race. Since obesity is a pathological condition affecting organ weight, these reference tables do not reflect normal organ weights but only weight as seen in severely and morbidly obese individuals. They should be useful to pathologists who perform forensic and non-forensic autopsies.
随着肥胖发病率的普遍上升，对重度和病态肥胖死者进行尸检在美国已变得很常见。器官重量的标准参考表几乎没有提供关于体重指数大于35 kg/m²个体的信息。尽管最近有几份报告提供了少量因各种原因自然死亡的病态肥胖者的器官重量数据，但这些数据可能受到合并症的影响。此外，它们没有提供基于性别、年龄和种族的器官重量差异的信息。本研究的目的是通过编制重度和病态肥胖个体的器官重量参考表来填补这一空白。我们的研究基于802例法医和医学尸检数据，包括435例自然死亡病例和367例非自然死亡病例。对这些组之间的器官重量进行了比较，并生成了参考范围。发现器官重量存在显著差异，尤其是在40岁以上自然死亡的死者中，这表明合并症会影响器官重量。根据性别、年龄和种族编制了器官重量和形态测量数据的参考表。由于肥胖是一种影响器官重量的病理状况，这些参考表不反映正常器官重量，而仅反映重度和病态肥胖个体中的器官重量。它们对进行法医和非法医尸检的病理学家应该是有用的。
