Muraru Denisa, Surkova Elena, Badano Luigi Paolo
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, School of Medicine, Padua, Italy.
Korean Circ J. 2016 Jul;46(4):443-55. doi: 10.4070/kcj.2016.46.4.443. Epub 2016 Jul 21.
Current knowledge of functional tricuspid regurgitation (FTR) as a progressive entity, worsening the prognosis of patients irrespective of its aetiology, has led to renewed interest in the pathophysiology and assessment of FTR. For the proper management of FTR, not only its severity, but also the mechanisms, the mode of leaflet coaptation, the degree of tricuspid annulus enlargement and leaflet tenting, and the haemodynamic consequences for right atrial and right ventricular morphology and function have to be taken into account. A better assessment of the anatomy and function of tricuspid apparatus and tricuspid regurgitation severity should help with the appropriate selection of patients who will benefit from either surgical tricuspid valve repair/replacement or a percutaneous procedure, especially among patients who are to undergo or have undergone primary left-sided valvular surgery. In this article, we review the anatomy, pathophysiology and the use of imaging techniques to assess patients with FTR, as well as the various treatment options for FTR, including emerging transcatheter procedures. The limitations affecting the current approach to FTR patients and the unmet clinical needs for their management have also been discussed.
目前关于功能性三尖瓣反流(FTR)作为一种进行性疾病的认识,即无论其病因如何,都会使患者预后恶化,这引发了人们对FTR病理生理学和评估的新兴趣。为了对FTR进行恰当管理,不仅要考虑其严重程度,还必须考虑其机制、瓣叶对合方式、三尖瓣环扩大程度和瓣叶帐篷样改变,以及对右心房和右心室形态及功能的血流动力学影响。更好地评估三尖瓣装置的解剖结构和功能以及三尖瓣反流的严重程度,应有助于适当选择将从外科三尖瓣修复/置换或经皮手术中获益的患者,尤其是那些即将接受或已经接受原发性左侧瓣膜手术的患者。在本文中,我们回顾了FTR患者的解剖结构、病理生理学以及评估所用的成像技术,以及FTR的各种治疗选择,包括新兴的经导管手术。还讨论了影响当前FTR患者治疗方法的局限性以及管理方面未满足的临床需求。