[The origin and treatment of accidents after the injection of penicillin].

In case of unintentional intravascular uptake, the injection of repository penicillin may produce severe embolic obturations. Several batches of respository penicillin were tested for their crystal size in ready-for-injection suspensions. The greatest crystals were found in preparations with a high proportion of benzylpenicillin-procaine. To avoid untoward reactions (Hoigné syndrome, Nicolau syndrome), the recommendations of the Central Expert Committe on Drugs must be considered. Furthermore, the measures required in case of anaphylactic shock are dealt with.