From the Department of Age-Related Health Care, Tallaght, Hospital, Dublin, Ireland
School of Medicine, Trinity College Dublin, Dublin, Ireland.
QJM. 2017 Jan;110(1):33-37. doi: 10.1093/qjmed/hcw114. Epub 2016 Aug 2.
Studies have demonstrated that a significant minority of older persons presenting to acute hospital services are cognitively impaired; however, the impact of dementia on long-term outcomes is less clear.
To evaluate the prevalence of dementia, both formally diagnosed and hitherto unrecognised in a cohort of acutely unwell older adults, as well as its impact on both immediate outcomes (length of stay and in-hospital mortality) and 12-month outcomes including readmission, institutionalisation and death.
Prospective observational study.
190 patients aged 70 years and over, presenting to acute hospital services underwent a detailed health assessment including cognitive assessment (standardised Mini Mental State Examination, AD8 and Confusion Assessment Method for the Intensive Care Unit). Patients or informants were contacted directly 12 months later to compile 1-year outcome data. Dementia was defined as a score of 2 or more on the AD8 screening test.
Dementia was present in over one-third of patients (73/190). Of these patients, 36% (26/73) had a prior documented diagnosis of dementia with the remaining undiagnosed before presentation. The composite outcome of death or readmission to hospital within the following 12 months was more likely to occur in patients with dementia (73% (53/73) vs. 58% (68/117), P = 0.043). This finding persisted after controlling for age, gender, frailty status and medical comorbidities, including stroke and heart disease.
A diagnosis of dementia confers an increased risk of either death or further admission within the following 12 months, highlighting the need for better cognitive screening in the acute setting, as well as targeted intervention such as comprehensive geriatric assessment.
研究表明,相当一部分到急症医院就诊的老年人存在认知障碍;然而,痴呆症对长期结果的影响尚不清楚。
评估急性不适的老年患者队列中痴呆症的患病率,包括正式诊断和以前未被识别的病例,并评估其对近期结果(住院时间和院内死亡率)以及 12 个月结果(包括再入院、机构化和死亡)的影响。
前瞻性观察研究。
190 名年龄在 70 岁及以上的患者,在急性医院就诊,接受了详细的健康评估,包括认知评估(标准化的简易精神状态检查、AD8 和重症监护病房的意识模糊评估法)。12 个月后,直接联系患者或其家属以收集 1 年的结果数据。痴呆症定义为 AD8 筛查测试得分为 2 或更高。
超过三分之一的患者(73/190)存在痴呆症。在这些患者中,36%(26/73)有先前记录的痴呆症诊断,其余患者在就诊前未被诊断。在接下来的 12 个月内死亡或再次入院的复合结局在痴呆症患者中更常见(73%(53/73)与 58%(68/117),P=0.043)。在控制年龄、性别、虚弱状态和包括中风和心脏病在内的合并症后,这一发现仍然存在。
痴呆症的诊断增加了在接下来的 12 个月内死亡或再次入院的风险,这突出表明需要在急症环境中进行更好的认知筛查,并进行有针对性的干预,如全面老年评估。