Cappello Maria, Morreale Gaetano C, Licata Anna
Gastroenterology and Hepatology Section, DIBIMIS, University of Palermo School of Medicine, Palermo, Italy.
Clin Med Insights Gastroenterol. 2016 Jul 27;9:41-9. doi: 10.4137/CGast.S38454. eCollection 2016.
Celiac sprue is a chronic disease, which usually occurs in children and young adults. However, it can develop in any age group, and the prevalence is increasing even in the elderly population. The atypical patterns of clinical presentation in this age group sometimes can cause a delay in diagnosis. Given the lower sensitivity and specificity of serological tests in the aged population, clinical suspect often arises in the presence of complications (autoimmune disorders, fractures, and finally, malignancy) and must be supported by endoscopic and imaging tools. In this review, we highlight the incidence and prevalence of celiac disease in the elderly, the patterns of clinical presentation, diagnosis, and the most frequent complications, with the aim of increasing awareness and reducing the diagnostic delay of celiac disease even in the elderly population.
乳糜泻是一种慢性疾病，通常发生于儿童和年轻人。然而，它可在任何年龄组发病，甚至在老年人群中患病率也在上升。该年龄组非典型的临床表现模式有时会导致诊断延迟。鉴于血清学检测在老年人群中敏感性和特异性较低，临床怀疑往往出现在有并发症（自身免疫性疾病、骨折，最终是恶性肿瘤）的情况下，且必须借助内镜和影像学检查手段来辅助诊断。在本综述中，我们着重介绍了老年人群中乳糜泻的发病率和患病率、临床表现模式、诊断方法以及最常见的并发症，目的是提高人们的认识，即使在老年人群中也能减少乳糜泻的诊断延迟。
