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Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.阿卡替尼（ACP-196）用于复发的慢性淋巴细胞白血病
N Engl J Med. 2016 Jan 28;374(4):323-32. doi: 10.1056/NEJMoa1509981. Epub 2015 Dec 7.
2
ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development.处于临床开发阶段的ABT-199（维奈托克）及BCL-2抑制剂
J Hematol Oncol. 2015 Nov 20;8:129. doi: 10.1186/s13045-015-0224-3.
3
The isolated extranodal relapse of the isolated extranodal non- Hodgkin lymphoma: A case report.孤立性结外非霍奇金淋巴瘤的孤立性结外复发：一例报告。
J Cancer Res Ther. 2015 Jul-Sep;11(3):645. doi: 10.4103/0973-1482.147706.
4
Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia.博纳吐单抗：一种用于难治性急性淋巴细胞白血病的抗CD19/CD3双特异性T细胞衔接器（BiTE）抗体。
J Hematol Oncol. 2015 Sep 4;8:104. doi: 10.1186/s13045-015-0195-4.
5
AFM13: a first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy.AFM13：一种用于自然杀伤细胞介导的免疫疗法的一流四价双特异性抗CD30/CD16A抗体。
J Hematol Oncol. 2015 Aug 1;8:96. doi: 10.1186/s13045-015-0188-3.
6
Nonpegylated Liposomal Doxorubicin as a Component of R-CHOP Is an Effective and Safe Alternative to Conventional Doxorubicin in the Treatment of Patients With Diffuse Large B-Cell Lymphoma and Preexisting Cardiac Diseases.非聚乙二醇化脂质体阿霉素作为R-CHOP方案的组成部分，在治疗弥漫性大B细胞淋巴瘤和已有心脏疾病的患者中，是传统阿霉素有效且安全的替代药物。
Clin Lymphoma Myeloma Leuk. 2015 Aug;15(8):458-63. doi: 10.1016/j.clml.2015.03.008. Epub 2015 Mar 24.
7
Selective inhibitors of nuclear export (SINE) in hematological malignancies.血液系统恶性肿瘤中的核输出选择性抑制剂（SINE）
Exp Hematol Oncol. 2015 Mar 1;4:7. doi: 10.1186/s40164-015-0002-5. eCollection 2015.
8
Long-term follow-up of dose-adjusted EPOCH plus rituximab (DA-EPOCH-R) in untreated patients with poor prognosis large B-cell lymphoma. A phase II study conducted by the Spanish PETHEMA Group.剂量调整的EPOCH联合利妥昔单抗（DA-EPOCH-R）方案用于初治预后不良的大B细胞淋巴瘤患者的长期随访。西班牙PETHEMA研究组开展的一项II期研究。
Br J Haematol. 2015 Apr;169(2):188-98. doi: 10.1111/bjh.13273. Epub 2014 Dec 18.
9
Pegylated liposomal doxorubicin replacing conventional doxorubicin in standard R-CHOP chemotherapy for elderly patients with diffuse large B-cell lymphoma: an open label, single arm, phase II trial.聚乙二醇化脂质体阿霉素在老年弥漫性大B细胞淋巴瘤患者标准R-CHOP化疗中替代传统阿霉素的开放标签、单臂、II期试验。
Clin Lymphoma Myeloma Leuk. 2015 Mar;15(3):152-8. doi: 10.1016/j.clml.2014.09.001. Epub 2014 Sep 28.
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Ibrutinib for B cell malignancies.伊布替尼治疗 B 细胞恶性肿瘤。
Exp Hematol Oncol. 2014 Jan 28;3(1):4. doi: 10.1186/2162-3619-3-4.

一名老年患者上肢弥漫性大B细胞淋巴瘤酷似软组织肉瘤的罕见病例。

A rare case of the upper extremity diffuse large B-cell lymphoma mimicking soft tissue sarcoma in an elderly patient.

作者信息

Mamorska-Dyga Aleksandra, Ronny Faisal M H, Puccio Carmelo, Islam Humayun, Liu Delong

机构信息

1 Department of Medicine, 2 Department of Pathology, New York Medical College and Westchester Medical Center, Valhalla, NY, USA.

出版信息

Stem Cell Investig. 2016 Jun 24;3:25. doi: 10.21037/sci.2016.06.06. eCollection 2016.

DOI:10.21037/sci.2016.06.06
PMID:27486587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4958056/
Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, with about 30% of new cases presenting with extranodal disease. Lesions originating from soft tissues of the upper extremities are extremely rare and may mimic other malignancies like sarcoma. We present a case of an elderly patient with right upper extremity (RUE) mass which was proven to be DLBCL instead of sarcoma. We emphasize the increasing need for investigating new therapeutic options for patients of extreme age and/or with underlying heart disease.

摘要

弥漫性大B细胞淋巴瘤（DLBCL）是最常见的非霍奇金淋巴瘤类型，约30%的新发病例表现为结外病变。起源于上肢软组织的病变极为罕见，可能类似肉瘤等其他恶性肿瘤。我们报告一例老年患者，其右上肢肿块经证实为DLBCL而非肉瘤。我们强调，对于高龄和/或患有基础心脏病的患者，越来越需要探索新的治疗选择。