Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
J Org Chem. 2016 Sep 2;81(17):7393-9. doi: 10.1021/acs.joc.6b00981. Epub 2016 Aug 11.
In this work, two xanthene dyes (H-hNR and TF-hNR) have been synthesized by a convenient and efficient method. These two dyes exhibited deep-red and near-infrared emissions, high fluorescence quantum yields, and good photostability. Their structure-optical properties were investigated by X-ray crystal structure analysis and density functional theory calculations. Live cell imaging data revealed that H-hNR and TF-hNR could rapidly stain both A549 and HeLa cells with low concentrations. The excellent photophysical and imaging properties render them as promising candidates for use in live cell imaging.
在这项工作中，我们通过一种方便、高效的方法合成了两种呫吨染料（H-hNR 和 TF-hNR）。这两种染料具有深红色和近红外发射、高荧光量子产率和良好的光稳定性。通过 X 射线晶体结构分析和密度泛函理论计算研究了它们的结构-光学性质。活细胞成像数据表明，H-hNR 和 TF-hNR 可以在低浓度下快速染色 A549 和 HeLa 细胞。优异的光物理和成像性能使它们成为活细胞成像的有前途的候选物。
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