Tyagi Natasha, Suneja Amita, Mishra Kiran, Jain Sandhya, Vaid Neelam Bala, Guleria Kiran
Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
Gynecol Obstet Invest. 2017;82(2):157-162. doi: 10.1159/000446948. Epub 2016 Aug 4.
To assess the feasibility and efficacy of Keyes punch biopsy instrument (KP) in diagnosing cervical lesions and compare it with cervical punch biopsy forceps (CP).
75 women having satisfactory colposcopy with abnormal transformation zone were included and paired colposcopic directed biopsies were taken using KP followed by CP from the same target area.
It was feasible in all cases to take cervical biopsy with KP after increasing its effective length. The volume of gross specimen obtained by KP was less than CP (0.076 ± 0.097 vs. 0.101 ± 0.156 cm3, p = 0.061), however on microscopic examination, mean length and mean depth of tissue in KP was greater than CP by 0.06 mm (p = 0.810) and 0.14 mm (p = 0.634) respectively. Exact agreement was found with the final surgical specimen in 42% of cases in both the biopsy forceps.
KP is almost at par with CP for diagnosing preinvasive cervical lesions and is a useful adjunct to the existing armamentarium of biopsy forceps.
评估凯斯穿刺活检器械（KP）诊断宫颈病变的可行性和有效性，并将其与宫颈穿刺活检钳（CP）进行比较。
纳入75例阴道镜检查满意且转化区异常的女性，在阴道镜引导下对同一目标区域先使用KP进行配对活检，随后再使用CP进行活检。
增加KP的有效长度后，在所有病例中均可进行宫颈活检。KP获取的大体标本体积小于CP（0.076±0.097 vs. 0.101±0.156 cm³，p = 0.061），然而在显微镜检查中，KP组织的平均长度和平均深度分别比CP长0.06 mm（p = 0.810）和0.14 mm（p = 0.634）。两种活检钳在42%的病例中与最终手术标本完全一致。
在诊断宫颈浸润前病变方面，KP与CP几乎相当，是现有活检钳设备的一种有用补充。
