Herzog V, Günther A, Meyer M, Belger B
Institut für Allgemeine und Kommunale Hygiene der Medizinischen Akademie Erfurt.
Pharmazie. 1989 Mar;44(3):204-6.
Certain pre-conditions given, the microbial contamination of pancreatin in powder form can be reduced below international standard values. However, each of the methods whether physical or chemical, causes a variable loss of activity depending on the methods applied and the concentration of the decontaminating agent used. Therefore during preparation of this complex enzymatic compound, highly aseptic conditions must be kept in all stages of the process to avoid an increase of germal contamination. For a final toxicological assessment of the decontaminated products, further tests are required.
在给定某些前提条件下,粉末状胰酶的微生物污染可降低至国际标准值以下。然而,无论是物理方法还是化学方法,每种方法都会因所应用的方法和所用去污剂的浓度而导致不同程度的活性损失。因此,在制备这种复合酶制剂的过程中,必须在所有阶段保持高度无菌条件,以避免微生物污染增加。对于去污产品的最终毒理学评估,还需要进一步的测试。