el-Sedawy A I, Shu Y Z, Hattori M, Kobashi K, Namba T
Planta Med. 1989 Apr;55(2):147-50. doi: 10.1055/s-2006-961909.
The biotransformation of swertiamarin [1, a seco-iridoid glucoside isolated from Swertia japonica (Schult.) Makino] by human intestinal bacteria was investigated. Three metabolites were isolated and identified as erythrocentaurin (2), 5-hydroxymethylisochroman-1-one (3), and gentianine (4) by spectroscopic methods. Through screening of various defined strains of intestinal bacteria (25 species), it was found that all these species had the ability to metabolize 1 to 2 and 3, whereas only a few species had the ability to produce 4. This is the first report to show that one of the metabolic intermediates of the secoiridoid compound is further transformed to a nitrogen-containing compound through metabolic processes by human intestinal bacteria.
研究了獐牙菜苦苷[1，一种从日本獐牙菜（Schult.）Makino中分离得到的裂环环烯醚萜苷]在人肠道细菌作用下的生物转化。通过光谱方法分离并鉴定出三种代谢产物，分别为红百金花素（2）、5-羟甲基异色满-1-酮（3）和龙胆宁碱（4）。通过对各种特定的肠道细菌菌株（25种）进行筛选，发现所有这些菌株都有将1代谢为2和3的能力，而只有少数菌株有产生4的能力。这是首次报道裂环环烯醚萜化合物的一种代谢中间体通过人肠道细菌的代谢过程进一步转化为含氮化合物。
