Calvo Gómez Carlos, Gómez-Huelgas Ricardo, Lima Ruiz Joan, Masmiquel Comas Lluis, Michán Doña Alfredo, Zapatero Gaviria Antonio
Int J Clin Pharmacol Ther. 2016 Nov;54(11):880-890. doi: 10.5414/CP202428.
Type 2 diabetes mellitus (DM2) is a disease of epidemic proportions. In the adult Spanish population, prevalence of DM2 is nearly 14%, which makes its monitoring and treatment imperative. Liraglutide has achieved relevance due to its efficacy and safety in DM treatment. The aim of this study is to gather expert opinion on diabetes to assess the current role of liraglutide in DM2.
MATERIALS/METHODS: The survey was performed by 57 internal medicine specialists using the Delphi method. The questionnaire had 56 items regarding liraglutide in DM treatment.
Consensus was reached in 71.4% of items. Panelists stated agreement regarding liraglutide suitability in the treatment of patients with DM2, high cardiovascular risk, and with pathologies related to obesity, highlighting its role in weight loss, low risk of hypoglycemia, and improvement of vascular risks. Moreover, consensus was not reached regarding the suitability of liraglutide in patients with special situations, mainly due to minimal experience caused by the small number of patients.
Due to its safety and hypoglycemic efficacy, liraglutide is an excellent choice for DM treatment in combination with other drugs. Its effects on the reduction of weight and other cardiovascular risk factors, make it an optimal treatment, especially in overweight or obese patients.
2型糖尿病(DM2)是一种流行病。在西班牙成年人群中,DM2的患病率接近14%,这使得对其进行监测和治疗势在必行。利拉鲁肽因其在糖尿病治疗中的疗效和安全性而受到关注。本研究的目的是收集糖尿病领域专家的意见,以评估利拉鲁肽在DM2治疗中的当前作用。
材料/方法:由57名内科专家采用德尔菲法进行调查。问卷包含56项关于利拉鲁肽在糖尿病治疗方面的内容。
71.4%的项目达成了共识。专家组成员对利拉鲁肽适用于治疗DM2患者、心血管风险高的患者以及与肥胖相关疾病的患者表示认同,强调了其在减肥、低血糖风险低以及改善血管风险方面的作用。此外,对于利拉鲁肽在特殊情况患者中的适用性未达成共识,主要原因是患者数量少导致经验有限。
由于其安全性和降糖疗效,利拉鲁肽是与其他药物联合用于糖尿病治疗的极佳选择。其对减轻体重和其他心血管危险因素的作用,使其成为一种最佳治疗方法,尤其是在超重或肥胖患者中。