Mashura Hanna Y, Hanych Taras M, Rishko Alexander A
Department of Faculty Therapy, Medical Faculty, Uzhhorod National University, Gryboyedova street, 10, 88000 Uzhhorod, Ukraine Tel.: (0312)64-36-52 e-mail:
Department of Faculty Therapy, Medical Faculty, Uzhhorod National University, Uzhhorod, Ukraine.
Wiad Lek. 2016;69(2 Pt 2):204-7.
Nonalcoholic fatty liver disease and hypertensive disease - is the most common combination of abnormalities that occur in people suffering from metabolic syndrome. Their combination not only causes concurrent damage of the liver and the heart, caused by common pathogenic beginning, and also mutually complicate the disease course of each other. The leading role in the development of nonalcoholic fatty liver disease belongs to abdominal obesity and insulin resistance, and is seen as a manifestation of liver disease in metabolic syndrome. Genetic predisposition, lifestyle, improper nutrition, including excessive use of sodium chloride, lead to excessive formation of visceral adipose tissue with development of abdominal obesity, which is a likely criterion of insulin resistance. The long course of nonalcoholic fatty liver disease in combination with essential hypertension in excessive consumption of sodium chloride may negatively affect their quality of life. The aim of the study is to find out the features of quality of life in patients with nonalcoholic fatty liver disease in combination with hypertensive disease with different taste sensitivity to sodium chloride.
We have investigated the quality of life of 65 patients with nonalcoholic fatty liver disease in combination with hypertensive disease II stage with different taste sensitivity to sodium chloride. Salt taste sensitivity threshold to sodium chloride is determined by the method of R. Henkin. Assessment of quality of life was performed using the Ukrainian version of the questionnaire Medical Outcomes Study Short Form 36 (MO S SF-36).
Was revealed that in patients with nonalcoholic fatty liver disease in combination with hypertensive disease II stage with high salt taste sensitivity threshold observed the decline in the quality of life that manifests as a decline in physical condition (especially of the physical functioning, physical role functioning and general health perceptions) and mental health (especially social functioning). Also the increased salt intake and salt appetite in patients with high salt taste sensitivity threshold were noted (p <0,05).
Reducing the use of sodium chloride can be a preventive measure easier than a decrease in body weight, and one that will reduce the body weight, especially in people with nonalcoholic fatty liver disease in combination with hypertensive disease, can reduce the risk of complications and improve quality of life in patients.
非酒精性脂肪性肝病和高血压病——是代谢综合征患者中最常见的异常组合。它们的合并不仅因共同的致病根源导致肝脏和心脏同时受损，还会使彼此的病程相互复杂化。腹部肥胖和胰岛素抵抗在非酒精性脂肪性肝病的发展中起主导作用，被视为代谢综合征中肝脏疾病的一种表现。遗传易感性、生活方式、营养不当，包括过量摄入氯化钠，会导致内脏脂肪组织过度形成，进而发展为腹部肥胖，这可能是胰岛素抵抗的一个标准。在过量摄入氯化钠的情况下，非酒精性脂肪性肝病与原发性高血压的长期病程可能会对患者的生活质量产生负面影响。本研究的目的是找出对氯化钠有不同味觉敏感性的非酒精性脂肪性肝病合并高血压病患者的生活质量特征。
我们调查了65例非酒精性脂肪性肝病合并II期高血压病且对氯化钠有不同味觉敏感性的患者的生活质量。采用R. 亨金法测定对氯化钠的盐味敏感阈值。使用乌克兰版的医学结局研究简表36（MOS SF - 36）问卷对生活质量进行评估。
研究发现，在对氯化钠有高盐味敏感阈值的非酒精性脂肪性肝病合并II期高血压病患者中，生活质量下降，表现为身体状况（尤其是身体功能、身体角色功能和总体健康感知）和心理健康（尤其是社会功能）下降。还注意到高盐味敏感阈值患者的盐摄入量和盐食欲增加（p<0.05）。
减少氯化钠的摄入量可能比减轻体重更容易成为一种预防措施，而且对于减轻体重，尤其是对于非酒精性脂肪性肝病合并高血压病的患者来说，减少氯化钠摄入量可以降低并发症风险并改善患者的生活质量。
