Leffa Daniela D, Daumann Francine, Damiani Adriani P, Afonso Arlindo C, Santos Maria A, Pedro Thayara H, Souza Renan P, Andrade Vanessa M
Laboratório de Biologia Celular e Molecular, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitaria, 1105 Bloco S, Criciuma, SC, 88806-100, Brazil.
Grupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Metab Brain Dis. 2017 Feb;32(1):51-55. doi: 10.1007/s11011-016-9885-z. Epub 2016 Aug 3.
Adjuvant therapy is a common therapeutic strategy used for schizophrenia management. Oxytocin has shown promising results as antipsychotic adjuvant in patients with schizophrenia. Although short-term clinical studies have indicated tolerability and no major side-effect manifestation, long-term studies remain needed. In this study, we investigated whether oxytocin chronic administration in rats may lead to brain DNA damage by comet assay. Our results suggest that 21 and 56-day treatment with once daily intraperitoneal oxytocin (0.1, 1.0 and 10.0 mg/kg) may cause substantial DNA damage in hippocampus. We have not found differences on body weight gain. Our findings also point that further clinical and preclinical studies evaluating oxytocin safety after chronic exposure are necessary.
辅助治疗是用于精神分裂症管理的常见治疗策略。催产素已显示出作为精神分裂症患者抗精神病辅助药物的有前景的结果。尽管短期临床研究表明了耐受性且无主要副作用表现，但仍需要长期研究。在本研究中，我们通过彗星试验研究了大鼠长期给予催产素是否可能导致脑DNA损伤。我们的结果表明，每天腹腔注射一次催产素（0.1、1.0和10.0毫克/千克）进行21天和56天的治疗可能会在海马体中造成大量DNA损伤。我们未发现体重增加方面的差异。我们的研究结果还指出，有必要进一步开展临床和临床前研究来评估长期接触催产素后的安全性。
