Kader I, Leavers B, Shashinder S, Wylie B, Chi K-K, Sundaresan P
Department of Otolaryngology/ Head and Neck Surgery,Gosford,New South Wales,Australia.
Central Coast Clinical School,University of Newcastle,Gosford,New South Wales,Australia.
J Laryngol Otol. 2016 Jul;130 Suppl 4:S45-9. doi: 10.1017/S002221511600832X.
To review our experience of managing patients with a dual diagnosis of metastatic cutaneous squamous cell carcinoma in the head and neck region and low-grade non-Hodgkin lymphoma. The secondary aim was to evaluate the utility of 18F-fluorodeoxyglucose positron emission tomography during diagnosis.
Patients diagnosed with metastatic cutaneous squamous cell carcinoma of the head and neck and low-grade non-Hodgkin lymphoma, in a five-year period, were identified. Patient, tumour and treatment characteristics were identified. 18F-fluorodeoxyglucose positron emission tomography imaging was reviewed and correlated with histopathology findings.
Eight patients were identified. There was a delay in diagnosis of metastatic squamous cell carcinoma in two patients. 18F-fluorodeoxyglucose positron emission tomography differentiated metastatic squamous cell carcinoma from low-grade non-Hodgkin lymphoma with a sensitivity of 88.2 per cent and a specificity of 94.7 per cent. In 38 per cent of patients, compromises in management had to be made.
The management of metastatic squamous cell carcinoma can be challenging in patients with low-grade non-Hodgkin lymphoma. 18F-fluorodeoxyglucose positron emission tomography can be useful in the diagnosis of metastatic squamous cell carcinoma in patients with low-grade non-Hodgkin lymphoma.
回顾我们对头颈部转移性皮肤鳞状细胞癌和低度非霍奇金淋巴瘤双重诊断患者的管理经验。次要目的是评估18F-氟脱氧葡萄糖正电子发射断层扫描在诊断过程中的效用。
确定在五年期间被诊断为头颈部转移性皮肤鳞状细胞癌和低度非霍奇金淋巴瘤的患者。确定患者、肿瘤和治疗特征。回顾18F-氟脱氧葡萄糖正电子发射断层扫描成像并与组织病理学结果相关联。
共确定8例患者。2例患者转移性鳞状细胞癌诊断存在延迟。18F-氟脱氧葡萄糖正电子发射断层扫描区分转移性鳞状细胞癌和低度非霍奇金淋巴瘤的灵敏度为88.2%，特异性为94.7%。38%的患者在管理上不得不做出妥协。
对于低度非霍奇金淋巴瘤患者，转移性鳞状细胞癌的管理可能具有挑战性。18F-氟脱氧葡萄糖正电子发射断层扫描在低度非霍奇金淋巴瘤患者转移性鳞状细胞癌的诊断中可能有用。
