Headache Science Centre, C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
J Headache Pain. 2016 Dec;17(1):70. doi: 10.1186/s10194-016-0661-6. Epub 2016 Aug 4.
Menstrually-related headache and headaches associated with oestrogen withdrawal are common conditions, whose pathophysiology has not been completely elucidated. In this study we evaluated the influence of combined hormonal contraceptives (CHC) on pain threshold in women presenting migraine attacks during hormone-free interval.
Eleven women with migraine attacks recurring exclusively during the oestrogen-withdrawal period were studied with the nociceptive flexion reflex, a neurophysiological assessment of the pain control systems, during the third week of active treatment and during the hormone-free interval. During the hormone-free interval, nociceptive withdrawal reflex threshold was significantly lower (12.8 ± 8.0 mA) as compared to the third week of hormonal treatment (15.6 ± 6.6 mA) (p = 0.02). No change was observed in the pain perceived and in the temporal summation.
Oestrogen withdrawal may mediate an increased sensitivity to somatosensory stimuli in women with migraine attacks recurring during the hormone-free interval.
与月经相关的头痛和与雌激素撤退相关的头痛是常见病症，其病理生理学尚未完全阐明。在这项研究中，我们评估了联合激素避孕药（CHC）对在激素撤退期出现偏头痛发作的女性疼痛阈值的影响。
我们研究了 11 名仅在雌激素撤退期出现偏头痛发作的女性，在激素治疗的第三周和激素撤退期使用伤害性屈反射（一种评估疼痛控制系统的神经生理学评估方法）。在激素撤退期，伤害性撤回反射阈值明显低于（12.8±8.0 mA）激素治疗的第三周（15.6±6.6 mA）（p=0.02）。在疼痛感知和时间总和方面没有观察到变化。
雌激素撤退可能介导在激素撤退期出现偏头痛发作的女性对躯体感觉刺激的敏感性增加。
