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一名印度女性出现奥硝唑诱发的共济失调:病例报告。

Ornidazole-induced ataxia in an Indian woman: A case report.

作者信息

Gopinath Kango Gopal, Wilson Benny Paul, Viggeswarpu Surekha, Mathews Prasad K, Mani Sunithi

机构信息

Department of Geriatric Medicine, Christian Medical College (CMC), Vellore, India.

Department of Radiology, Christian Medical College (CMC), Vellore, India.

出版信息

SAGE Open Med Case Rep. 2015 Dec 15;3:2050313X15621857. doi: 10.1177/2050313X15621857. eCollection 2015.

DOI:10.1177/2050313X15621857
PMID:27489705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4857303/
Abstract

The nitroimidazole group of antibiotics like metronidazole have been reported to cause cerebellar ataxia as a rare side effect. Ornidazole, the newest derivative of this class, has a long half life and is very rarely known to cause cerebellar ataxia. Here, we report a 61-year-old patient who developed ataxia due to ornidazole to highlight an unusual adverse event that improved rapidly after discontinuation of the offending drug.

摘要

据报道,像甲硝唑这类抗生素的硝基咪唑基团会引起小脑共济失调,这是一种罕见的副作用。奥硝唑是此类药物的最新衍生物,半衰期长,极少会引起小脑共济失调。在此,我们报告一名61岁因奥硝唑导致共济失调的患者,以突出这一不寻常的不良事件,该事件在停用致病药物后迅速好转。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2e9/4857303/bf581dd3caaa/10.1177_2050313X15621857-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2e9/4857303/bf581dd3caaa/10.1177_2050313X15621857-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2e9/4857303/bf581dd3caaa/10.1177_2050313X15621857-fig1.jpg

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本文引用的文献

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Metronidazole induced cerebellar ataxia.甲硝唑引起的小脑性共济失调。
Indian J Pharmacol. 2013 May-Jun;45(3):295-7. doi: 10.4103/0253-7613.111903.
2
Methyl bromide poisoning presenting as acute ataxia.以急性共济失调为表现的溴甲烷中毒
Neurol India. 2011 Sep-Oct;59(5):768-9. doi: 10.4103/0028-3886.86561.
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Quinolones: review of psychiatric and neurological adverse reactions.喹诺酮类药物:精神和神经系统不良反应综述。
一名中国男性的奥硝唑诱发复发性脑病:罕见病例报告及文献综述
Front Neurol. 2021 Sep 9;12:706094. doi: 10.3389/fneur.2021.706094. eCollection 2021.
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J Neurol Neurosurg Psychiatry. 2010 Mar;81(3):349-50. doi: 10.1136/jnnp.2009.178897.
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Cerebellar ataxia following prolonged use of metronidazole: case report and literature review.长期使用甲硝唑后出现的小脑共济失调:病例报告及文献综述
Int J Infect Dis. 2008 Nov;12(6):e111-4. doi: 10.1016/j.ijid.2008.03.006. Epub 2008 Jun 3.
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MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings.甲硝唑诱导性脑病的磁共振成像:病变分布及扩散加权成像表现
AJNR Am J Neuroradiol. 2007 Oct;28(9):1652-8. doi: 10.3174/ajnr.A0655. Epub 2007 Sep 20.
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