Domico Michele, Allen Meredith
1Department of Pediatrics, Section of Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Children's Hospital of Orange County Orange, CA. 2Section of Critical Care Medicine, Royal Children's Hospital, Melbourne, Parkville, VIC, Australia.
Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S215-21. doi: 10.1097/PCC.0000000000000778.
In this review, we discuss the physiology, pathophysiology, and clinical role of troponin, lactate, and B-type natriuretic peptide in the assessment and management of children with critical cardiac disease.
MEDLINE, PubMed.
Lactate, troponin, and B-type natriuretic peptide continue to be valuable biomarkers in the assessment and management of critically ill children with cardiac disease. However, the use of these markers as a single measurement is handicapped by the wide variety of clinical scenarios in which they may be increased. The overall trend may be more useful than any single level with a persistent or rising value of more importance than an elevated initial value.
在本综述中，我们讨论肌钙蛋白、乳酸和B型利钠肽在危重心脏病患儿评估和管理中的生理学、病理生理学及临床作用。
医学在线数据库（MEDLINE）、医学期刊数据库（PubMed）。
乳酸、肌钙蛋白和B型利钠肽在患有心脏病的危重症患儿的评估和管理中仍然是有价值的生物标志物。然而，由于它们可能升高的临床情况种类繁多，将这些标志物作为单一测量指标存在局限性。总体趋势可能比任何单一水平更有用，持续或上升的值比初始升高的值更重要。
