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本文引用的文献

1
A review of sepsis-induced cardiomyopathy.脓毒症相关性心肌病研究综述
J Intensive Care. 2015 Nov 11;3:48. doi: 10.1186/s40560-015-0112-5. eCollection 2015.
2
The prevalence and diagnostic utility of systemic inflammatory response syndrome vital signs in a pediatric emergency department.小儿急诊科全身炎症反应综合征生命体征的患病率及诊断效用
Acad Emerg Med. 2015 Apr;22(4):381-9. doi: 10.1111/acem.12610. Epub 2015 Mar 16.
3
Systemic inflammatory response syndrome criteria in defining severe sepsis.全身性炎症反应综合征标准在严重脓毒症中的应用。
N Engl J Med. 2015 Apr 23;372(17):1629-38. doi: 10.1056/NEJMoa1415236. Epub 2015 Mar 17.
4
Trial of early, goal-directed resuscitation for septic shock.早期目标导向性复苏治疗脓毒性休克的试验。
N Engl J Med. 2015 Apr 2;372(14):1301-11. doi: 10.1056/NEJMoa1500896. Epub 2015 Mar 17.
5
Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study.儿童严重脓毒症的全球流行病学：脓毒症患病率、转归及治疗研究
Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57. doi: 10.1164/rccm.201412-2323OC.
6
Developing a clinically feasible personalized medicine approach to pediatric septic shock.开发一种针对儿童脓毒性休克的临床可行的个性化医疗方法。
Am J Respir Crit Care Med. 2015 Feb 1;191(3):309-15. doi: 10.1164/rccm.201410-1864OC.
7
Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis.皮质类固醇与小儿感染性休克结局：风险分层分析。
PLoS One. 2014 Nov 11;9(11):e112702. doi: 10.1371/journal.pone.0112702. eCollection 2014.
8
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study.拯救脓毒症运动：一项为期7.5年的研究中绩效指标与结果之间的关联
Crit Care Med. 2015 Jan;43(1):3-12. doi: 10.1097/CCM.0000000000000723.
9
Goal-directed resuscitation for patients with early septic shock.目标导向性复苏治疗早期感染性休克患者。
N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.
10
Pediatric severe sepsis in U.S. children's hospitals.美国儿童医院中的儿童严重脓毒症
Pediatr Crit Care Med. 2014 Nov;15(9):798-805. doi: 10.1097/PCC.0000000000000225.

小儿心脏重症监护中的脓毒症

Sepsis in Pediatric Cardiac Intensive Care.

作者信息

Wheeler Derek S, Wong Hector R

机构信息

Both authors: Department of Pediatrics, Section of Critical Care Medicine, Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

出版信息

Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S266-71. doi: 10.1097/PCC.0000000000000796.

DOI:10.1097/PCC.0000000000000796
PMID:27490609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4975434/
Abstract

OBJECTIVES

In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function.

DATA SOURCE

MEDLINE and PubMed.

CONCLUSIONS

There is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. However, at the same time, it is also evident that sepsis mortality has not improved enough, even with progress in our understanding of the molecular pathophysiology of sepsis.

摘要

目的

在本综述中，我们将讨论脓毒症发生的危险因素；生物标志物在早期诊断、监测治疗效果、分层以及识别脓毒症内型中的作用；以及严重脓毒症和脓毒性休克的病理生理学与管理，重点关注脓毒症对心血管功能的影响。

数据来源

MEDLINE和PubMed。

结论

当今脓毒症研究领域令人兴奋。脓毒症诊断和临床分期方面的科学进展以及脓毒症的个性化治疗方法为未来带来了巨大希望。然而，与此同时，即便我们对脓毒症分子病理生理学的理解有所进步，脓毒症死亡率仍未得到足够改善这一点也很明显。