小儿心脏重症监护中的脓毒症
Sepsis in Pediatric Cardiac Intensive Care.
作者信息
Wheeler Derek S, Wong Hector R
机构信息
Both authors: Department of Pediatrics, Section of Critical Care Medicine, Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
出版信息
Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S266-71. doi: 10.1097/PCC.0000000000000796.
Abstract
OBJECTIVES
In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function.
DATA SOURCE
MEDLINE and PubMed.
CONCLUSIONS
There is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. However, at the same time, it is also evident that sepsis mortality has not improved enough, even with progress in our understanding of the molecular pathophysiology of sepsis.
摘要
目的
在本综述中，我们将讨论脓毒症发生的危险因素；生物标志物在早期诊断、监测治疗效果、分层以及识别脓毒症内型中的作用；以及严重脓毒症和脓毒性休克的病理生理学与管理，重点关注脓毒症对心血管功能的影响。
数据来源
MEDLINE和PubMed。
结论
当今脓毒症研究领域令人兴奋。脓毒症诊断和临床分期方面的科学进展以及脓毒症的个性化治疗方法为未来带来了巨大希望。然而，与此同时，即便我们对脓毒症分子病理生理学的理解有所进步，脓毒症死亡率仍未得到足够改善这一点也很明显。
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