拉莫三嗪脑炎患者脑组织中人乳头瘤病毒抗原的表达升高。
Elevated expression of human papillomavirus antigen in brain tissue of patients with Rasmussen's encephalitis.
作者信息
Chen Shuai, Chen Sichang, Guan Yuguang, Zhang Yao, Qi Xueling, An Jing, Wang Yisong, Luan Guoming
机构信息
Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China; Beijing Key Laboratory of Epilepsy, Beijing 100093, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China.
Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China; Beijing Key Laboratory of Epilepsy, Beijing 100093, China.
出版信息
Epilepsy Res. 2016 Oct;126:119-25. doi: 10.1016/j.eplepsyres.2016.07.008. Epub 2016 Jul 27.
OBJECTS
To investigate the expression of human papillomavirus (HPV)-specific antigen in the brain tissue of patients with Rasmussen's Encephalitis (RE) and its possible link to the clinical manifestation of RE.
METHODS
The correlation between RE and HPV antigen expression in brain tissue sections was investigated using immunohistochemical (IHC) staining, pathological examination, MRI and clinical manifestations.
RESULTS
HPV antigen expression was elevated in three out of four patients with RE, whereas there were no detectable HPV antigens in six control patients. Significant staining for HPV antigen was located mainly around or in the nucleus and cytoplasm of neurons. Among these RE patients, three with elevated expression of HPV antigens had obvious hemisphere atrophy, whereas the patient with negative staining for HPV antigens had mild atrophy.
CONCLUSIONS
Elevated expression of HPV antigens was observed in the brain tissue of RE patients, which may correlate with hemisphere atrophy. Thus, our results may suggest that HPV infection or being a carrier of HPV may play a role in the initiation and progression of RE.
目的
研究人乳头瘤病毒（HPV）特异性抗原在拉斯穆森脑炎（RE）患者脑组织中的表达及其与RE临床表现的可能联系。
方法
采用免疫组织化学（IHC）染色、病理检查、MRI及临床表现，研究脑组织切片中RE与HPV抗原表达之间的相关性。
结果
4例RE患者中有3例HPV抗原表达升高，而6例对照患者中未检测到HPV抗原。HPV抗原的显著染色主要位于神经元的细胞核和细胞质周围或内部。在这些RE患者中，3例HPV抗原表达升高的患者有明显的半球萎缩，而HPV抗原染色阴性的患者有轻度萎缩。
结论
在RE患者的脑组织中观察到HPV抗原表达升高，这可能与半球萎缩相关。因此，我们的结果可能提示HPV感染或作为HPV携带者可能在RE的发生和发展中起作用。
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