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桡动脉作为冠状动脉旁路移植术的桥血管:20 年的结果。

Radial Artery as a Coronary Artery Bypass Conduit: 20-Year Results.

机构信息

Department of Cardiovascular Sciences, Catholic University, Rome, Italy; Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York.

Department of Cardiovascular Sciences, Catholic University, Rome, Italy.

出版信息

J Am Coll Cardiol. 2016 Aug 9;68(6):603-610. doi: 10.1016/j.jacc.2016.05.062.

Abstract

BACKGROUND

There is a lack of evidence for the choice of the second conduit in coronary surgery. The radial artery (RA) is a possible option, but few data on very-long-term outcomes exist.

OBJECTIVES

This study describes 20-year results of RA grafts used for coronary artery bypass grafting and the effects of RA removal on forearm circulation.

METHODS

We report the results of the prospective 20-year follow-up of the first 100 consecutive patients who received the RA as a coronary bypass conduit at our institution.

RESULTS

Follow-up was 100% complete. There were 64 deaths, 23 (35.9%) from cardiovascular causes. Kaplan-Meier 20-year survival was 31%. Of the 36 survivors, 33 (91.6%) underwent RA graft control at a mean of 19.0 ± 2.5 years after surgery. The RA was found to be patent in 24 cases (84.8% patency). In the overall population, probability of graft failure at 20 years was 19.0 ± 0.2% for the left internal thoracic artery (ITA), 25.0 ± 0.2% for the RA, and 55.0 ± 0.2% for the saphenous vein (p = 0.002 for RA vs. saphenous vein, 0.11 for RA vs. ITA, and p < 0.001 for ITA vs. saphenous vein). Target vessel stenosis >90%, but not location of distal anastomosis, significantly influenced long-term RA graft patency. No patients reported hand or forearm symptoms. The ulnar artery diameter was increased in the operated arm (2.44 ± 0.43 mm vs. 2.01 ± 0.47 mm; p < 0.05) and correlated with the peak systolic velocity of the second palmar digital artery (Pearson coefficient: 0.621; p < 0.05).

CONCLUSIONS

The 20-year patency rate of RA grafts is good, and not inferior to the ITA, especially when the conduit is used to graft a vessel with >90% stenosis. RA harvesting does not lead to hand or forearm symptoms, even at a very-long-term follow-up.

摘要

背景

在冠状动脉手术中,对于第二个移植物的选择缺乏证据。桡动脉(RA)是一种可能的选择,但关于其非常长期结果的数据很少。

目的

本研究描述了 RA 移植物用于冠状动脉旁路移植术的 20 年结果,以及 RA 移除对前臂循环的影响。

方法

我们报告了在我们机构接受 RA 作为冠状动脉旁路移植物的前 100 例连续患者的前瞻性 20 年随访结果。

结果

随访率为 100%。有 64 例死亡,其中 23 例(35.9%)死于心血管原因。Kaplan-Meier 20 年生存率为 31%。在 36 名存活者中,33 名(91.6%)在手术后平均 19.0±2.5 年进行了 RA 移植物控制。在整个队列中,左内乳动脉(ITA)、RA 和隐静脉的 20 年移植物失败率分别为 19.0±0.2%、25.0±0.2%和 55.0±0.2%(RA 与隐静脉相比,p=0.002;RA 与 ITA 相比,p=0.11;ITA 与隐静脉相比,p<0.001)。靶血管狭窄>90%,但不包括远端吻合口位置,显著影响 RA 移植物的长期通畅率。没有患者报告手部或前臂症状。手术侧的尺动脉直径增加(2.44±0.43mm 比 2.01±0.47mm;p<0.05),并与第二掌指动脉收缩期峰值流速相关(Pearson 系数:0.621;p<0.05)。

结论

RA 移植物的 20 年通畅率良好,并不逊于 ITA,尤其是当移植物用于吻合>90%狭窄的血管时。RA 采集不会导致手部或前臂症状,即使在非常长期的随访中也是如此。

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