成人的高流量介导的血管收缩不受心血管和代谢风险生物标志物的影响。
High-flow-mediated constriction in adults is not influenced by biomarkers of cardiovascular and metabolic risk.
作者信息
Ostrem Joseph D, Evanoff Nicholas G, Ryder Justin R, Steinberger Julia, Sinaiko Alan R, Bisch Katie L, Brinck Niklas M, Dengel Donald R
机构信息
Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, 55455.
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, 55455.
出版信息
J Clin Ultrasound. 2017 Jan;45(1):35-42. doi: 10.1002/jcu.22387. Epub 2016 Aug 5.
PURPOSE
During reactive hyperemia, the brachial artery in some individuals constricts prior to dilation. Our aim was to describe the frequency of high-flow-mediated constriction (H-FMC) in adults, and its relationship to body composition and biomarkers of cardiovascular and metabolic risk.
METHODS
Two hundred forty-six adults (124 male, 122 female; 36 ± 7 years old) were assessed for H-FMC via sonographic imaging of the brachial artery. Blood pressure, glucose, insulin, lipids, and body composition assessed via dual energy X-ray absorptiometry were collected. H-FMC was characterized as a 10-second average of maximal postocclusion constriction. Independent t test was used to compare H-FMC versus non-H-FMC individuals.
RESULTS
H-FMC was observed in approximately 69% of adult participants (54 obese, 57 overweight, and 59 normal weight). Total body mass (82.3 ± 17.5 versus 76.3 ± 16.3 kg, p = 0.012), fat mass (27.7 ± 11.5 versus 23.8 ± 10.5 kg, p = 0.012), body mass index (27.7 ± 4.9 versus 26.1 ± 5.0 kg/m , p = 0.018), and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (2.41 ± 1.03 versus 2.09 ± 0.72, p = 0.007) were higher in H-FMC than in non-H-FMC individuals. Flow-mediated dilatation (FMD) (6.12 ± 3.48 versus 8.09 ± 3.02%, p < 0.001) was lower in H-FMC subjects. However, there was no difference in brachial artery dilation between groups (7.57 ± 3.69 versus 8.09 ± 3.02%, p = 0.250) when H-FMC was added to FMD.
CONCLUSIONS
Increased body mass, fat mass, and body mass index were associated with a greater H-FMC. When H-FMC was present, the FMD response to reactive hyperemia was significantly lower. Because H-FMC has been observed to negatively affect FMD response to reactive hyperemia, we suggest that H-FMC should be noted when analyzing and interpreting FMD data. H-FMC may be an ancillary measure of endothelial health. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:35-42, 2017.
目的
在反应性充血期间，部分个体的肱动脉在扩张前会出现收缩。我们的目的是描述成年人中高流量介导的收缩（H-FMC）的发生率，及其与身体组成以及心血管和代谢风险生物标志物之间的关系。
方法
通过肱动脉超声成像对246名成年人（124名男性，122名女性；36±7岁）进行H-FMC评估。收集通过双能X线吸收法评估的血压、血糖、胰岛素、血脂和身体组成数据。H-FMC被定义为闭塞后最大收缩的10秒平均值。采用独立t检验比较H-FMC个体与非H-FMC个体。
结果
约69%的成年参与者（54名肥胖、57名超重和59名正常体重者）观察到H-FMC。H-FMC个体的总体重（82.3±17.5对76.3±16.3kg，p = 0.012）、脂肪量（27.7±11.5对23.8±10.5kg，p = 0.012）、体重指数（27.7±4.9对26.1±5.0kg/m²，p = 0.018）以及低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值（2.41±1.03对2.09±0.72，p = 0.007）均高于非H-FMC个体。H-FMC受试者的血流介导的扩张（FMD）（6.12±3.48对8.09±3.02%，p < 0.001）较低。然而，当将H-FMC加入FMD时，两组之间的肱动脉扩张无差异（7.57±3.69对8.09±3.02%，p = 0.250）。
结论
体重、脂肪量和体重指数增加与更高的H-FMC相关。当存在H-FMC时，对反应性充血的FMD反应显著降低。由于已观察到H-FMC会对反应性充血的FMD反应产生负面影响，我们建议在分析和解释FMD数据时应注意H-FMC。H-FMC可能是内皮健康的一项辅助指标。©2016威利期刊公司。《临床超声杂志》45:35 - 42，2017。
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