Ostrem Joseph D, Evanoff Nicholas G, Ryder Justin R, Dengel Donald R
Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN, USA.
Kinesiology and Health Sciences, College of Education and Science, Concordia University - St. Paul, St. Paul, MN, USA.
Clin Physiol Funct Imaging. 2018 Mar;38(2):200-205. doi: 10.1111/cpf.12399. Epub 2016 Dec 26.
Previously, we have demonstrated that high-flow-mediated constriction (H-FMC) of the brachial artery has been shown to negatively affect flow-mediated dilation (FMD). However, the reproducibility of an H-FMC response is unknown.
The aim of this study was to determine the intra- and interday reproducibility of H-FMC in young adults.
Thirty young adults (15 male, 15 female; 24 ± 3 years) were assessed for H-FMC reproducibility via high-resolution ultrasound imaging of the brachial artery during and after forearm occlusion of a normal FMD procedure. Two vascular assessments were conducted for all participants during two separate visits with a minimum of 7 days in between. H-FMC was characterized as the greatest 10-s average constriction occurring after 3-s postocclusion compared to baseline brachial artery diameter and considered present if the percent change was <-0·1%.
Of the 120 total vascular assessments performed in this study, 98 of the assessments (80·3%) displayed an H-FMC. H-FMC diameter was not statistically different for intraday comparisons for visit 1 (P = 0·39) or visit 2 (P = 0·55) or interday comparisons between the first (P = 0·61) or second (P = 0·10) assessments. H-FMC percentage was also not statistically different for intra-day comparison for visit 1 (P = 0·94) or visit 2 (P = 0·15) or interday comparisons between the first (P = 0·63) or second (P = 0·16) assessments.
These data are supportive of H-FMC being reproducible in young adults and included in future FMD studies. The impact of H-FMC on future CVD risk and development warrants evaluation.
此前，我们已经证明肱动脉的高流量介导收缩（H-FMC）已被证明会对血流介导的舒张（FMD）产生负面影响。然而，H-FMC反应的可重复性尚不清楚。
本研究的目的是确定年轻成年人中H-FMC的日内和日间可重复性。
通过在正常FMD程序的前臂闭塞期间和之后对肱动脉进行高分辨率超声成像，对30名年轻成年人（15名男性，15名女性；24±3岁）进行H-FMC可重复性评估。在两次单独的就诊期间对所有参与者进行两次血管评估，两次就诊之间至少间隔7天。H-FMC被定义为与基线肱动脉直径相比，闭塞后3秒后出现的最大10秒平均收缩，如果百分比变化<-0.1%则认为存在H-FMC。
在本研究中进行的120次总血管评估中，98次评估（80.3%）显示存在H-FMC。对于第1次就诊（P=0.39）或第2次就诊（P=0.55）的日内比较，以及第1次（P=0.61）或第2次（P=0.10）评估之间的日间比较，H-FMC直径无统计学差异。对于第1次就诊（P=0.94）或第2次就诊（P=0.15）的日内比较，以及第1次（P=0.63）或第2次（P=0.16）评估之间的日间比较，H-FMC百分比也无统计学差异。
这些数据支持H-FMC在年轻成年人中具有可重复性，并可纳入未来的FMD研究。H-FMC对未来心血管疾病风险和发展的影响值得评估。
