• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

靶向ROS-HIF-1-内皮素轴作为治疗阻塞性睡眠呼吸暂停相关心血管并发症的一种治疗方法。

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications.

作者信息

Belaidi Elise, Morand Jessica, Gras Emmanuelle, Pépin Jean-Louis, Godin-Ribuot Diane

机构信息

Université Grenoble Alpes, Laboratoire HP2, Grenoble F-38042, France; INSERM U1042, Grenoble F-38042, France.

Université Grenoble Alpes, Laboratoire HP2, Grenoble F-38042, France; INSERM U1042, Grenoble F-38042, France; CHU de Grenoble, Grenoble F-38042, France.

出版信息

Pharmacol Ther. 2016 Dec;168:1-11. doi: 10.1016/j.pharmthera.2016.07.010. Epub 2016 Aug 2.

DOI:10.1016/j.pharmthera.2016.07.010
PMID:27492897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5643507/
Abstract

Obstructive sleep apnea (OSA) is now recognized as an independent and important risk factor for cardiovascular diseases such as hypertension, coronary heart disease, heart failure and stroke. Clinical and experimental data have confirmed that intermittent hypoxia is a major contributor to these deleterious consequences. The repetitive occurrence of hypoxia-reoxygenation sequences generates significant amounts of free radicals, particularly in moderate to severe OSA patients. Moreover, in addition to hypoxia, reactive oxygen species (ROS) are potential inducers of the hypoxia inducible transcription factor-1 (HIF-1) that promotes the transcription of numerous adaptive genes some of which being deleterious for the cardiovascular system, such as the endothelin-1 gene. This review will focus on the involvement of the ROS-HIF-1-endothelin signaling pathway in OSA and intermittent hypoxia and discuss current and potential therapeutic approaches targeting this pathway to treat or prevent cardiovascular disease in moderate to severe OSA patients.

摘要

阻塞性睡眠呼吸暂停（OSA）现已被公认为是高血压、冠心病、心力衰竭和中风等心血管疾病的一个独立且重要的危险因素。临床和实验数据已证实，间歇性缺氧是这些有害后果的主要促成因素。缺氧-复氧序列的反复发生会产生大量自由基，尤其是在中重度OSA患者中。此外，除了缺氧之外，活性氧（ROS）还是缺氧诱导转录因子-1（HIF-1）的潜在诱导剂，HIF-1可促进众多适应性基因的转录，其中一些基因对心血管系统有害，例如内皮素-1基因。本综述将重点关注ROS-HIF-1-内皮素信号通路在OSA和间歇性缺氧中的作用，并讨论针对该通路的现有及潜在治疗方法，以治疗或预防中重度OSA患者的心血管疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/f32e21036160/halms1369186f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/932bb2a9f5ea/halms1369186f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/472c799a4f1a/halms1369186f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/07d171f40361/halms1369186f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/f32e21036160/halms1369186f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/932bb2a9f5ea/halms1369186f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/472c799a4f1a/halms1369186f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/07d171f40361/halms1369186f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61a5/5643507/f32e21036160/halms1369186f4.jpg

相似文献

1
Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications.靶向ROS-HIF-1-内皮素轴作为治疗阻塞性睡眠呼吸暂停相关心血管并发症的一种治疗方法。
Pharmacol Ther. 2016 Dec;168:1-11. doi: 10.1016/j.pharmthera.2016.07.010. Epub 2016 Aug 2.
2
Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea.在阻塞性睡眠呼吸暂停动物模型中，缺氧诱导因子-1和内皮素系统在促进心肌梗死和高血压方面的主要作用。
J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17. doi: 10.1016/j.jacc.2008.12.050.
3
Obstructive sleep apnea: the new cardiovascular disease. Part I: Obstructive sleep apnea and the pathogenesis of vascular disease.阻塞性睡眠呼吸暂停：一种新的心血管疾病。第一部分：阻塞性睡眠呼吸暂停与血管疾病的发病机制。
Heart Fail Rev. 2009 Sep;14(3):143-53. doi: 10.1007/s10741-008-9112-z. Epub 2008 Sep 20.
4
Obstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms.阻塞性睡眠呼吸暂停与心血管后果：病理生理机制。
Arch Cardiovasc Dis. 2020 May;113(5):350-358. doi: 10.1016/j.acvd.2020.01.003. Epub 2020 Mar 26.
5
Obstructive sleep apnea, stroke, and cardiovascular diseases.阻塞性睡眠呼吸暂停、中风与心血管疾病。
Neurologist. 2010 Nov;16(6):329-39. doi: 10.1097/NRL.0b013e3181f097cb.
6
Vascular changes, cardiovascular disease and obstructive sleep apnea.血管变化、心血管疾病与阻塞性睡眠呼吸暂停。
Future Cardiol. 2011 Mar;7(2):241-9. doi: 10.2217/fca.10.123.
7
Consequences of Obstructive Sleep Apnea: Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk.阻塞性睡眠呼吸暂停的后果：阻塞性睡眠呼吸暂停的心血管风险以及持续气道正压通气是否能降低该风险。
Sleep Med Clin. 2016 Sep;11(3):273-86. doi: 10.1016/j.jsmc.2016.05.002.
8
Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases.阻塞性睡眠呼吸暂停及相关心血管疾病中的氧化应激与氧化信号传导
Free Radic Biol Med. 2006 May 15;40(10):1683-92. doi: 10.1016/j.freeradbiomed.2006.01.008. Epub 2006 Feb 2.
9
Oxidative stress in obstructive sleep apnea and intermittent hypoxia--revisited--the bad ugly and good: implications to the heart and brain.阻塞性睡眠呼吸暂停和间歇性低氧中的氧化应激——再探——坏的、丑的和好的：对心脏和大脑的影响。
Sleep Med Rev. 2015 Apr;20:27-45. doi: 10.1016/j.smrv.2014.07.003. Epub 2014 Jul 24.
10
Obstructive sleep apnea and cardiovascular disease: a perspective and future directions.阻塞性睡眠呼吸暂停与心血管疾病：一种观点及未来方向
Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):434-51. doi: 10.1016/j.pcad.2009.01.002.

引用本文的文献

1
Pathophysiological Mechanisms of Diabetes-Induced Macrovascular and Microvascular Complications: The Role of Oxidative Stress.糖尿病诱导的大血管和微血管并发症的病理生理机制：氧化应激的作用
Med Sci (Basel). 2025 Jul 2;13(3):87. doi: 10.3390/medsci13030087.
2
Novel anoikis-related diagnostic biomarkers for aortic dissection based on machine learning.基于机器学习的主动脉夹层新型失巢凋亡相关诊断生物标志物
Sci Rep. 2024 Dec 28;14(1):31314. doi: 10.1038/s41598-024-82655-6.
3
Exploring the pharmacological mechanisms for alleviating OSA: Adenosine A2A receptor downregulation of the PI3K/Akt/HIF‑1 pathway (Review).探索缓解阻塞性睡眠呼吸暂停的药理机制：腺苷A2A受体对PI3K/Akt/HIF-1通路的下调作用（综述）
Biomed Rep. 2024 Nov 28;22(2):21. doi: 10.3892/br.2024.1899. eCollection 2025 Feb.
4
Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data.间歇性缺氧诱导的脑氧化应激、炎症和细胞凋亡：对啮齿动物数据的系统评价和荟萃分析
Eur Respir Rev. 2024 Dec 18;33(174). doi: 10.1183/16000617.0162-2024. Print 2024 Oct.
5
The positional characteristics of patients with obstructive sleep apnea: a single institute retrospective study in Japan.阻塞性睡眠呼吸暂停患者的位置特征：日本一项单机构回顾性研究
Sleep Biol Rhythms. 2021 Sep 14;20(1):115-121. doi: 10.1007/s41105-021-00347-4. eCollection 2022 Jan.
6
Evaluation of nocturnal apnea and airflow limitation as indicators for cognitive dysfunction in patients with chronic obstructive pulmonary disease/obstructive sleep apnea hypopnea syndrome overlap syndrome.评估慢性阻塞性肺疾病/阻塞性睡眠呼吸暂停低通气综合征重叠综合征患者夜间呼吸暂停和气流受限作为认知功能障碍的指标。
Chron Respir Dis. 2024 Jan-Dec;21:14799731241236492. doi: 10.1177/14799731241236492.
7
4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) alleviates lung injury by inhibiting SIRT6-HIF-1α signaling pathway activation through the upregulation of miR-212-5p expression.4-羟基-2,2,6,6-四甲基哌啶-1-氧自由基（Tempol）通过上调 miR-212-5p 的表达抑制 SIRT6-HIF-1α 信号通路的激活，从而减轻肺损伤。
Mol Biol Rep. 2024 Jan 18;51(1):129. doi: 10.1007/s11033-023-09039-3.
8
Chronic intermittent hypoxia due to obstructive sleep apnea slightly alters nutritional status: a pre-clinical study.阻塞性睡眠呼吸暂停导致的慢性间歇性缺氧对营养状况有轻微影响：一项临床前研究。
Front Nutr. 2023 Oct 30;10:1250529. doi: 10.3389/fnut.2023.1250529. eCollection 2023.
9
Associations between insomnia and large vessel occlusion acute ischemic stroke: An observational study.失眠与大血管闭塞性急性缺血性脑卒中的相关性：一项观察性研究。
Clinics (Sao Paulo). 2023 Nov 2;78:100297. doi: 10.1016/j.clinsp.2023.100297. eCollection 2023.
10
The role of HIF-1α/HO-1 pathway in hippocampal neuronal ferroptosis in epilepsy.缺氧诱导因子-1α/血红素加氧酶-1通路在癫痫海马神经元铁死亡中的作用
iScience. 2023 Sep 29;26(11):108098. doi: 10.1016/j.isci.2023.108098. eCollection 2023 Nov 17.

本文引用的文献

1
Obstructive sleep apnoea syndrome.阻塞性睡眠呼吸暂停综合征。
Nat Rev Dis Primers. 2015 Jun 25;1:15015. doi: 10.1038/nrdp.2015.15.
2
Endoplasmic reticulum stress as a novel inducer of hypoxia inducible factor-1 activity: its role in the susceptibility to myocardial ischemia-reperfusion induced by chronic intermittent hypoxia.内质网应激作为缺氧诱导因子-1活性的新型诱导剂：其在慢性间歇性缺氧诱导的心肌缺血再灌注易感性中的作用。
Int J Cardiol. 2016 May 1;210:45-53. doi: 10.1016/j.ijcard.2016.02.096. Epub 2016 Feb 17.
3
Melatonin and the von Hippel-Lindau/HIF-1 oxygen sensing mechanism: A review.褪黑素与冯·希佩尔-林道/缺氧诱导因子-1氧感应机制：综述
Biochim Biophys Acta. 2016 Apr;1865(2):176-83. doi: 10.1016/j.bbcan.2016.02.004. Epub 2016 Feb 17.
4
Intermittent Hypoxia-Induced Cardiovascular Remodeling Is Reversed by Normoxia in a Mouse Model of Sleep Apnea.间歇性低氧诱导的心血管重构在睡眠呼吸暂停小鼠模型中通过常氧得以逆转。
Chest. 2016 Jun;149(6):1400-8. doi: 10.1016/j.chest.2015.11.010. Epub 2016 Jan 13.
5
Association Between the Severity of Nocturnal Hypoxia in Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Damage.阻塞性睡眠呼吸暂停低通气综合征夜间低氧血症严重程度与非酒精性脂肪肝损伤的关系
Hepat Mon. 2015 Nov 28;15(11):e32655. doi: 10.5812/hepatmon.32655. eCollection 2015 Nov.
6
Increased internalization of complement inhibitor CD59 may contribute to endothelial inflammation in obstructive sleep apnea.补体抑制剂CD59内化增加可能导致阻塞性睡眠呼吸暂停中的内皮炎症。
Sci Transl Med. 2016 Jan 6;8(320):320ra1. doi: 10.1126/scitranslmed.aad0634.
7
Endothelin-1 mediates intermittent hypoxia-induced inflammatory vascular remodeling through HIF-1 activation.内皮素-1通过激活缺氧诱导因子-1介导间歇性缺氧诱导的炎症性血管重塑。
J Appl Physiol (1985). 2016 Feb 15;120(4):437-43. doi: 10.1152/japplphysiol.00641.2015. Epub 2015 Dec 17.
8
Endothelin regulates intermittent hypoxia-induced lipolytic remodelling of adipose tissue and phosphorylation of hormone-sensitive lipase.内皮素调节间歇性低氧诱导的脂肪组织脂解重塑及激素敏感性脂肪酶的磷酸化。
J Physiol. 2016 Mar 15;594(6):1727-40. doi: 10.1113/JP271321. Epub 2016 Jan 20.
9
Comparison of continuous positive airway pressure and bosentan effect in mildly hypertensive patients with obstructive sleep apnoea: A randomized controlled pilot study.持续气道正压通气与波生坦对轻度高血压阻塞性睡眠呼吸暂停患者疗效的比较：一项随机对照试验性研究
Respirology. 2016 Apr;21(3):546-52. doi: 10.1111/resp.12713. Epub 2015 Dec 8.
10
CPAP vs Mandibular Advancement Devices and Blood Pressure in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis.CPAP 与下颌前移装置治疗阻塞性睡眠呼吸暂停患者的血压：系统评价和荟萃分析。
JAMA. 2015 Dec 1;314(21):2280-93. doi: 10.1001/jama.2015.16303.