Jellusova Julia, Rickert Robert C
a BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg , Freiburg , Germany.
b Max Planck Institute of Immunobiology and Epigenetics , Freiburg , Germany.
Crit Rev Biochem Mol Biol. 2016 Sep;51(5):359-378. doi: 10.1080/10409238.2016.1215288. Epub 2016 Aug 5.
B cell growth and proliferation is tightly regulated by signaling through the B cell receptor and by other membrane bound receptors responding to different cytokines. The PI3K signaling pathway has been shown to play a crucial role in B cell activation, differentiation and survival. Activated B cells undergo metabolic reprograming in response to changing energetic and biosynthetic demands. B cells also need to be able to coordinate metabolic activity and proliferation with nutrient availability. The PI3K signaling network has been implicated in regulating nutrient acquisition, utilization and biosynthesis, thus integrating receptor-mediated signaling with cell metabolism. In this review, we discuss the current knowledge about metabolic changes induced in activated B cells, strategies to adapt to metabolic stress and the role of PI3K signaling in these processes.
B细胞的生长和增殖受到通过B细胞受体的信号传导以及其他对不同细胞因子作出反应的膜结合受体的严格调控。PI3K信号通路已被证明在B细胞的激活、分化和存活中起关键作用。活化的B细胞会根据不断变化的能量和生物合成需求进行代谢重编程。B细胞还需要能够根据营养物质的可利用性来协调代谢活动和增殖。PI3K信号网络参与调节营养物质的获取、利用和生物合成，从而将受体介导的信号传导与细胞代谢整合起来。在这篇综述中，我们讨论了关于活化B细胞中诱导的代谢变化、适应代谢应激的策略以及PI3K信号在这些过程中的作用的当前知识。
