Wu Xin Yin, Du Xin Jian, Ho Robin S T, Lee Clarence C Y, Yip Benjamin H K, Wong Martin C S, Wong Samuel Y S, Chung Vincent C H
Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, China.
J Clin Hypertens (Greenwich). 2017 Feb;19(2):137-142. doi: 10.1111/jch.12889. Epub 2016 Aug 6.
Methodological quality of meta-analyses on hypertension treatments can affect treatment decision-making. The authors conducted a cross-sectional study to investigate the methodological quality of meta-analyses on hypertension treatments. One hundred and fifty-eight meta-analyses were identified. Overall, methodological quality was unsatisfactory in the following aspects: comprehensive reporting of financial support (1.9%), provision of included and excluded lists of studies (22.8%), inclusion of grey literature (27.2%), and inclusion of protocols (32.9%). The 126 non-Cochrane meta-analyses had poor performance on almost all the methodological items. Non-Cochrane meta-analyses focused on nonpharmacologic treatments were more likely to consider scientific quality of included studies when making conclusions. The 32 Cochrane meta-analyses generally had good methodological quality except for comprehensive reporting of the sources of support. These results highlight the need for cautious interpretation of these meta-analyses, especially among physicians and policy makers when guidelines are formulated. Future meta-analyses should pay attention to improving these methodological aspects.
高血压治疗荟萃分析的方法学质量会影响治疗决策。作者开展了一项横断面研究，以调查高血压治疗荟萃分析的方法学质量。共识别出158项荟萃分析。总体而言，在以下方面方法学质量不尽人意：资金支持的全面报告（1.9%）、提供纳入和排除的研究列表（22.8%）、纳入灰色文献（27.2%）以及纳入研究方案（32.9%）。126项非Cochrane荟萃分析在几乎所有方法学项目上表现不佳。聚焦于非药物治疗的非Cochrane荟萃分析在得出结论时更有可能考虑纳入研究的科学质量。32项Cochrane荟萃分析除支持来源的全面报告外，总体方法学质量良好。这些结果凸显了对这些荟萃分析进行谨慎解读的必要性，尤其是在制定指南时医生和政策制定者当中。未来的荟萃分析应注意改进这些方法学方面。
