印度安达曼群岛与手足口病相关的柯萨奇病毒A16的B1c基因亚型
B1c genetic subtype of coxsackievirus A16 associated with hand, foot and mouth disease in Andaman Islands, India.
作者信息
Palani Surya, Nagarajan Muruganandam, Biswas Ashok Kumar, Maile Anwesh, Paluru Vijayachari
机构信息
Regional Medical Research Centre (ICMR), Department of Microbiology, Port Blair - 744101, Andaman and Nicobar Islands, India.
Regional Medical Research Centre (ICMR), Department of Microbiology, Port Blair - 744101, Andaman and Nicobar Islands, India
出版信息
Trans R Soc Trop Med Hyg. 2016 Jul;110(7):421-3. doi: 10.1093/trstmh/trw042.
BACKGROUND
An outbreak of hand, foot and mouth disease (HFMD) occurred in the Andaman Islands in 2013. Therefore, we aimed to identify the aetiological agent and to explore its genetic characteristics.
METHODS
Clinical specimens were subjected to virus isolation, further confirmed by sequencing the partial VP1/2A region of enterovirus, and analysed using MEGA 6 software with intra-serotype reference sequences.
RESULTS
Coxsackievirus A16 (CV A16) was found to be the causative agent, closely grouped with B1c genetic clusters of CV A16. However, it has significant genetic distance (K2P=0.059%) with B1c sub-clusters.
CONCLUSION
Extended research work should be carried out to better understand the emerging nature of CV A16 associated with HFMD in these islands.GenBank accession numbers: KU523376-KU523387.
背景
2013年安达曼群岛发生了手足口病（HFMD）疫情。因此，我们旨在确定病原体并探索其基因特征。
方法
临床标本进行病毒分离，通过对肠道病毒的部分VP1/2A区域进行测序进一步确认，并使用MEGA 6软件与血清型内参考序列进行分析。
结果
发现柯萨奇病毒A16（CV A16）是病原体，与CV A16的B1c基因簇紧密聚类。然而，它与B1c亚簇有显著的遗传距离（K2P = 0.059%）。
结论
应开展进一步的研究工作，以更好地了解这些岛屿上与手足口病相关的CV A16的新出现性质。GenBank登录号：KU523376 - KU523387。
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