Sarma Nilendu, Chakraborty Sayantani, Dutta Abira, Sadhukhan Provash Chandra
Department of Dermatology, Dr. B C Roy Post Graduate Institute of Pediatric Sciences, Kolkata - 700 010, West Bengal, India.
Department of Dermatology, R G Kar Medical College, Kolkata - 700 010, West Bengal, India.
Indian J Dermatol. 2017 Sep-Oct;62(5):486-490. doi: 10.4103/ijd.IJD_381_17.
Hand, foot, and mouth disease (HFMD), an enteroviral disease has emerged as a major emerging infection in India. This is caused most commonly by enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) but can also be due to CVA4-10, CVA24, CVB2-5, and echovirus 18 (Echo18). Virological analysis of the cases of HFMD has been infrequently done in India. West Bengal is one of the worst affected states in India.
To document the clinical and etiological aspect, the changing patterns and clinic-virological correlation. Method: a total of 62 samples of throat swab were collected from affected children over 3 successive years in Kolkata, West Bengal, India.
Five cases had a previous history of HFMD during the last 1-5 years. Fever was usually of mild degree (highest 102°C). There was no apparent correlation between fever of >100°C and a positive test. There was no correlation of viral strain and clinical severity. A test positive for the Viral RNA was noted among 64.51% (40/62) cases. Multiple strains were characteristically present in each year. CVA6, EV71 were found in 2013, CVA6, EV71 in 2014, and CVA6, CVA16 in 2015.
Presence of multiple strains explained the frequent occurrence of relapses. We expect this small study will serve as an important document for all future studies on HFMD.
手足口病（HFMD）是一种肠道病毒疾病，已成为印度主要的新发感染病。该病最常见由肠道病毒71型（EV71）和柯萨奇病毒A16型（CVA16）引起，但也可能由CVA4 - 10、CVA24、CVB2 - 5和埃可病毒18型（Echo18）导致。在印度，对手足口病病例进行病毒学分析的情况并不常见。西孟加拉邦是印度受影响最严重的邦之一。
记录临床和病因学方面、变化模式以及临床与病毒学的相关性。方法：在印度西孟加拉邦加尔各答，连续三年从患病儿童中总共采集了62份咽拭子样本。
5例患儿在过去1 - 5年内有手足口病病史。发热通常程度较轻（最高102°F）。体温>100°F与检测呈阳性之间无明显相关性。病毒株与临床严重程度无关。64.51%（40/62）的病例病毒RNA检测呈阳性。每年均有多种病毒株存在。2013年发现CVA6、EV71，2014年发现CVA6、EV71，2015年发现CVA6、CVA16。
多种病毒株的存在解释了复发的频繁发生。我们期望这项小型研究将成为未来所有手足口病研究的重要文献。
