北京基因型结核分枝杆菌在印度北部的流行情况及其与耐药性的关联。
Prevalence of Mycobacterium tuberculosis Beijing genotype and its association with drug resistance in North India.
作者信息
Mathuria Jitendra P, Srivastava Govind N, Sharma Pragya, Mathuria Bharat L, Ojha Sanjay, Katoch Vishwa M, Anupurba Shampa
机构信息
Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India; Department of Medical Lab technology, Paramedical Vigyaan Mahvidhalaya, Uttar Pradesh University of Medical Sciences, Saifai, India.
Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
出版信息
J Infect Public Health. 2017 Jul-Aug;10(4):409-414. doi: 10.1016/j.jiph.2016.06.007. Epub 2016 Aug 2.
The global presence and rapid dissemination of Beijing genotype of Mycobacterium tuberculosis, makes it an important issue of public health. Its presence and association with multi-drug resistance has been shown in many settings. In present study we tried to find its prevalence and association with drug resistance in North India. One hundred and twenty four M. tuberculosis isolates were analyzed with spoligotyping, further drug susceptibility testing was done by 1% proportional method. Out of these, 11 (8.9%) M. tuberculosis isolates were identified as Beijing and 113 (91.1%) as non-Beijing genotypes. While looking at their drug susceptibility patterns, 6 (54.5%) & 22 (19.5%) were found to be multi drug resistant (MDR) among Beijing and non-Beijing isolates respectively. Our study concluded that the Beijing strains were not so common in north India and these strains do not fully associate with MDR.
结核分枝杆菌北京基因型在全球的存在及其快速传播，使其成为一个重要的公共卫生问题。在许多情况下，已表明其存在以及与多重耐药性的关联。在本研究中，我们试图在印度北部找出其流行情况以及与耐药性的关联。对124株结核分枝杆菌分离株进行了间隔寡核苷酸分型分析，进一步通过1%比例法进行药物敏感性测试。其中，11株（8.9%）结核分枝杆菌分离株被鉴定为北京基因型，113株（91.1%）为非北京基因型。在观察它们的药物敏感性模式时，北京基因型和非北京基因型分离株中分别有6株（54.5%）和22株（19.5%）被发现为多重耐药（MDR）。我们的研究得出结论，北京菌株在印度北部并不常见，并且这些菌株与多重耐药性并不完全相关。
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