2nd Medical Faculty, Charles University, Bulovka Hospital, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.
Psoriasis and Skin Clinic, Melbourne, Australia.
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 3):89-93.
Candidal intertrigo is an infection of the skin caused by Candida albicans that typically occurs in opposing cutaneous or muco-cutaneous surfaces. Because Candidiasis requires a damaged and moist environment for infection, it typically occurs in areas of friction such as the skin folds of the body. Candidal intertrigo is often difficult to treat and results are often unsatisfactory. In addition, there is a lack of evidence-based literature supporting prevention and treatments for candidal intertrigo. The aim of the study was to evaluate the efficacy of Dr Michaels® (also branded as Fungatinex®) products in the treatment of fungal intertrigo, in 20 women and 2 men with a mean age of 72. Five patients (3 female and 2 male) had type 2 diabetes and 16 (14 female and 2 male) were obese. The patients were treated with Dr Michaels® (Fungatinex®) moisturising bar, topical ointment (twice daily application) and oral herbal formulation, PSC 200 two tablets twice daily with food. After 2 weeks of treatment, the lesions had mostly resolved in all patients with only slight erythema evident. After six weeks of treatment using the moisturising bar, topical ointment and oral herbal formulations from the Dr Michaels® (Fungatinex®) product family, the lesions had totally resolved in 18 patients, while 4 patients had to continue the therapeutic protocol for another 2 weeks. Our results demonstrate that the Dr Michaels® (Fungatinex®) complementary product family is efficacious in the treatment of recalcitrant candidal intertrigo. Furthermore, this study highlights that the Dr Michaels® (Fungatinex®) product family is fast-acting and well tolerated with no serious adverse events reported. These data have important implications for resistant cases of candidal intertrigo where traditional therapies have failed.
念珠菌性间擦疹是一种由白色念珠菌引起的皮肤感染,通常发生在对置的皮肤或黏膜表面。因为念珠菌感染需要受损和潮湿的环境,所以它通常发生在身体皮肤褶皱等摩擦部位。念珠菌性间擦疹通常难以治疗,结果往往不尽如人意。此外,缺乏支持念珠菌性间擦疹预防和治疗的循证文献。本研究旨在评估 Michaels 博士(也称为 Fungatinex®)产品治疗真菌性间擦疹的疗效,共纳入 20 名女性和 2 名男性患者,平均年龄为 72 岁。其中 5 名患者(3 名女性和 2 名男性)患有 2 型糖尿病,16 名(14 名女性和 2 名男性)肥胖。患者接受 Michaels 博士(Fungatinex®)保湿皂、局部软膏(每日两次应用)和口服草药配方 PSC 200(每日两次,每次两片,随餐服用)治疗。治疗 2 周后,所有患者的皮损大多消退,仅轻微红斑。治疗 6 周后,使用 Michaels 博士(Fungatinex®)保湿皂、局部软膏和口服草药配方,18 名患者皮损完全消退,4 名患者需继续治疗 2 周。我们的结果表明,Michaels 博士(Fungatinex®)补充产品系列在治疗难治性念珠菌性间擦疹方面是有效的。此外,本研究强调,Michaels 博士(Fungatinex®)产品系列起效迅速,耐受性良好,无严重不良事件报告。这些数据对于传统疗法失败的耐药性念珠菌性间擦疹病例具有重要意义。