Al-Jaderi Zaidoon, Maghazachi Azzam A
Department of Clinical Sciences, College of Medicine and Sahrjah Institute for Medical Research, University of Sharjah , Sharjah , United Arab Emirates.
Front Immunol. 2016 Jul 22;7:278. doi: 10.3389/fimmu.2016.00278. eCollection 2016.
Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl fumarate (DMF) is utilized as an oral drug to treat this disease and is proven to be potent with less side effects than several other drugs. On the other hand, monomethyl fumarate (MMF), a related compound, has not been examined in greater details although it has the potential as a therapeutic drug for MS and other diseases. The mechanism of action of DMF or MMF is related to their ability to enhance the antioxidant pathways and to inhibit reactive oxygen species. However, other mechanisms have also been described, which include effects on monocytes, dendritic cells, T cells, and natural killer cells. It is also reported that DMF might be useful for treating psoriasis, asthma, aggressive breast cancers, hematopoeitic tumors, inflammatory bowel disease, intracerebral hemorrhage, osteoarthritis, chronic pancreatitis, and retinal ischemia. In this article, we will touch on some of these diseases with an emphasis on the effects of DMF and MMF on various immune cells.
几种药物已被批准用于治疗多发性硬化症（MS）。富马酸二甲酯（DMF）被用作治疗该疾病的口服药物，并且已被证明效力强大，副作用比其他几种药物更少。另一方面，富马酸单甲酯（MMF），一种相关化合物，尽管有作为MS和其他疾病治疗药物的潜力，但尚未得到更详细的研究。DMF或MMF的作用机制与其增强抗氧化途径和抑制活性氧的能力有关。然而，也描述了其他机制，包括对单核细胞、树突状细胞、T细胞和自然杀伤细胞的影响。据报道，DMF可能对治疗银屑病、哮喘、侵袭性乳腺癌、血液肿瘤、炎症性肠病、脑出血、骨关节炎、慢性胰腺炎和视网膜缺血有用。在本文中，我们将探讨其中一些疾病，重点是DMF和MMF对各种免疫细胞的影响。
