Wedow Robbee, Briley Daniel A, Short Susan E, Boardman Jason D
Department of Sociology, University of Colorado, Boulder, CO, USA; Health and Society Program and Population Program, Institute of Behavioral Science, University of Colorado, Boulder, CO, USA; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
Department of Psychology, University of Illinois at Urbana-Champaign, USA.
Soc Sci Med. 2016 Sep;165:99-107. doi: 10.1016/j.socscimed.2016.07.044. Epub 2016 Aug 1.
In this paper, we investigate the possibility that genetic variation contributes to self-perceived weight status among adolescents and young adults in the U.S. Using samples of identical and fraternal twins across four waves of the National Longitudinal Study of Adolescent to Adult Health (Add Health) study, we calculate heritability estimates for objective body mass index (BMI) that are in line with previous estimates. We also show that perceived weight status is heritable (h(2) ∼ 0.47) and most importantly that this trait continues to be heritable above and beyond objective BMI (h(2) ∼ 0.25). We then demonstrate significant sex differences in the heritability of weight identity across the four waves of the study, where h(2)women = 0.39, 0.35, 0.40, and 0.50 for each wave, respectively, and h(2)men = 0.10, 0.10, 0.23, and 0.03. These results call for a deeper consideration of both identity and gender in genetics research.
在本文中,我们研究了基因变异对美国青少年和青年自我认知体重状况的影响。利用来自全国青少年健康纵向研究(Add Health)四个阶段的同卵双胞胎和异卵双胞胎样本,我们计算出的客观体重指数(BMI)遗传率估计值与先前的估计结果一致。我们还表明,自我认知的体重状况具有遗传性(h(2) ∼ 0.47),最重要的是,这一特征在客观BMI之外仍具有遗传性(h(2) ∼ 0.25)。然后,我们证明了在研究的四个阶段中,体重认知的遗传率存在显著的性别差异,其中女性在各阶段的h(2)分别为0.39、0.35、0.40和0.50,男性在各阶段的h(2)分别为0.10、0.10、0.23和0.03。这些结果呼吁在遗传学研究中更深入地考虑身份和性别因素。