线粒体蛋白质导入：一个意想不到的二硫键。

Biomedical Center Munich - Physiological Chemistry, LMU Munich, 82152 Martinsried, Germany

J Cell Biol. 2016 Aug 15;214(4):363-5. doi: 10.1083/jcb.201607117. Epub 2016 Aug 8.

Most mitochondrial proteins are imported through the TIM23 translocation channel, the structure and molecular nature of which are still unclear. In this issue, Ramesh et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602074) show that the TIM23 subunit Tim17 contains a disulfide bond that is crucial for protein translocation and channel gating.

大多数线粒体蛋白通过TIM23转运通道导入，其结构和分子性质仍不清楚。在本期中，拉梅什等人（2016年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201602074）表明，TIM23亚基Tim17含有一个二硫键，该二硫键对蛋白质转运和通道门控至关重要。

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Biomedical Center Munich - Physiological Chemistry, LMU Munich, 82152 Martinsried, Germany

J Cell Biol. 2016 Aug 15;214(4):363-5. doi: 10.1083/jcb.201607117. Epub 2016 Aug 8.

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A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import.

J Cell Biol. 2016 Aug 15;214(4):417-31. doi: 10.1083/jcb.201602074. Epub 2016 Aug 8.

Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system.

Mol Biol Cell. 2011 Oct;22(20):3758-67. doi: 10.1091/mbc.E11-04-0296. Epub 2011 Aug 24.

The disulfide relay of the intermembrane space oxidizes the ribosomal subunit mrp10 on its transit into the mitochondrial matrix.

Dev Cell. 2014 Jan 13;28(1):30-42. doi: 10.1016/j.devcel.2013.11.007. Epub 2013 Dec 19.

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Cell. 2008 Aug 8;134(3):439-50. doi: 10.1016/j.cell.2008.06.007.

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Antioxid Redox Signal. 2010 Nov 1;13(9):1359-73. doi: 10.1089/ars.2010.3099.

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引用本文的文献

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Cell Rep. 2018 Nov 27;25(9):2605-2616.e7. doi: 10.1016/j.celrep.2018.11.015.

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Elife. 2017 Feb 6;6:e22696. doi: 10.7554/eLife.22696.

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A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import.

J Cell Biol. 2016 Aug 15;214(4):417-31. doi: 10.1083/jcb.201602074. Epub 2016 Aug 8.

Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding.

Elife. 2016 Jun 25;5:e16177. doi: 10.7554/eLife.16177.

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线粒体蛋白质导入：一个意想不到的二硫键。

Mitochondrial protein import: An unexpected disulfide bond.

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