Centro de Oftalmología Barraquer, Universitat Internacional de Catalunya, Barcelona, Spain; Institut Universitari Barraquer, Universitat Autonoma de Barcelona, Barcelona, Spain.
Institut Universitari Barraquer, Universitat Autonoma de Barcelona, Barcelona, Spain.
Ocul Surf. 2016 Oct;14(4):495-506. doi: 10.1016/j.jtos.2016.07.002. Epub 2016 Aug 5.
To analyze the anatomical and functional results of keratoprosthesis using tibial bone autograft.
We reviewed 113 charts of patients who underwent tibial bone osteokeratoprothesis implantation at the Centro de Oftalmologia Barraquer. Kaplan-Meier survival curves with 95% confidence interval were calculated for functional success, defined as best corrected visual acuity (BCVA) ≥0.05 on the decimal scale, and for anatomical success, defined as retention of the keratoprosthesis lamina. Multivariate analysis was used to test the impact of clinical factors on anatomical and functional survival rates.
Based on Kaplan-Meier analyses, tibial bone keratoprosthesis 5-year and 10-year anatomical survival rates were 69.5% and 53.5%, respectively. Functional survival rate at 5 years was 33% and at 10 years was 19.2%. Considering primary diagnosis, chemical burn had better anatomical and functional survival rates than autoimmune or infectious diseases. Patient age did not have a significant effect on keratoprosthesis survival rates. About 48.7% of the patients who underwent surgery had complications: keratoprosthesis extrusion, glaucoma, retinal detachment and buccal mucosa necrosis were the most frequent ones.
Half of the patients with tibial bone KPro had retained the keratoprosthesis after 10 years post-surgery and one-fifth of them had visual acuity of 0.05 or better at the same period. Considering that these patients have no other way to recover their vision either because they have no canine tooth or their buccal or dental conditions are not adequate for OOKP, this modified surgery is their only hope.
分析使用胫骨自体骨移植物进行角膜假体的解剖学和功能结果。
我们回顾了在 Centro de Oftalmologia Barraquer 接受胫骨骨骨角膜假体植入的 113 例患者的病历。使用 Kaplan-Meier 生存曲线和 95%置信区间计算功能成功率,定义为十进制最佳矫正视力(BCVA)≥0.05;解剖成功率定义为保留角膜假体层。使用多变量分析测试临床因素对解剖和功能生存率的影响。
根据 Kaplan-Meier 分析,胫骨骨角膜假体 5 年和 10 年的解剖生存率分别为 69.5%和 53.5%。5 年的功能生存率为 33%,10 年的功能生存率为 19.2%。考虑到原发性诊断,化学烧伤的解剖和功能生存率优于自身免疫或感染性疾病。患者年龄对角膜假体生存率没有显著影响。大约 48.7%的手术患者出现并发症:角膜假体突出、青光眼、视网膜脱离和颊黏膜坏死是最常见的并发症。
术后 10 年,一半的胫骨 KPro 患者保留了角膜假体,其中五分之一的患者在同一时期的视力达到 0.05 或更好。考虑到这些患者由于没有犬齿或颊部或牙齿状况不适合 OOKP,无法恢复视力,因此这种改良手术是他们唯一的希望。