Piñeiro Pérez Roi, Santiago García Begoña, Rodríguez Marrodán Belén, Baquero-Artigao Fernando, Fernández-Llamazares Cecilia M, Goretti López-Ramos María, Vinent Genestar Joan, Gómez-Pastrana Durán David, Mellado Peña María José
Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Infectología Pediátrica (SEIP); Comité de Medicamentos de la Asociación Española de Pediatría (CM-AEP).
Red Española de Estudio de la Tuberculosis Pediátrica (pTBred); Sociedad Española de Infectología Pediátrica (SEIP).
An Pediatr (Barc). 2016 Dec;85(6):323.e1-323.e11. doi: 10.1016/j.anpedi.2016.06.012. Epub 2016 Aug 5.
The Spanish Network for the Study of Paediatric Tuberculosis has shown a lack of national consensus on the treatment of tuberculosis in children, partly due to the unavailability of paediatric presentations of antituberculosis drugs. The harmonisation of tuberculosis treatment in children is a priority in Spain. A joint action is proposed by a group of Spanish experts in childhood tuberculosis and in the area of Paediatric Pharmacology. To this end, a pTBred-led workgroup of members from five scientific bodies has been created. Drug pharmaceutical compounding in oral suspensions or oral solutions are recommended as follows: isoniazid 50mg/mL, pyrazinamide 100mg/mL, and ethambutol 50mg/mL. Raw materials, period of validity, and storage conditions are specified. Recommendations for the use of fixed-dose combination drugs are also established. If oral solutions/suspensions or fixed-dose combination drugs are not appropriate, the use of crushed tablets is recommended. Adherence to treatment and optimal dosing of antituberculosis drugs are critical in the control and eradication of TB. This multidisciplinary document provides an opportunity to promote the appropriate treatment of paediatric tuberculosis in Spain, and should become a useful tool for paediatricians and pharmacists.
西班牙儿童结核病研究网络表明，在儿童结核病治疗方面缺乏全国共识，部分原因是缺乏儿童剂型的抗结核药物。在西班牙，统一儿童结核病治疗是一项优先事项。一群西班牙儿童结核病专家和儿科药理学领域的专家提议采取联合行动。为此，成立了一个由pTBred牵头、来自五个科学机构的成员组成的工作组。建议口服混悬液或口服溶液的药物配制如下：异烟肼50mg/mL、吡嗪酰胺100mg/mL和乙胺丁醇50mg/mL。规定了原材料、有效期和储存条件。还制定了使用固定剂量复方药物的建议。如果口服溶液/混悬液或固定剂量复方药物不合适，建议使用压碎的片剂。坚持治疗和优化抗结核药物剂量对于控制和消除结核病至关重要。这份多学科文件为促进西班牙儿童结核病的适当治疗提供了契机，应成为儿科医生和药剂师的有用工具。
