Linder Dennis, Marinello Elena, Donisi Pietro Maria, Salmaso Roberto, Zattra Edoardo, Zampetti Anna
Section of Biostatistics, University of Oslo, Oslo, Norway.
Dermatology Unit, University of Padua, Padua, Italy.
Case Rep Dermatol. 2016 Jul 12;8(2):189-92. doi: 10.1159/000447482. eCollection 2016 May-Aug.
Darier's disease (DD) is an autosomal dominant inherited genodermatosis which is often under- or misdiagnosed. In the majority of cases, the disease manifests in adolescents or young adults with small brownish-yellow, warty, hyperkeratotic papules in multiple seborrheic areas of the body. Localized DD (LDD) is a clinical variant, first described by Kreibich in 1906; only a few cases are reported in the literature. We described the case of an aged woman presenting with LDD, and we review the literature on this subject.
Darier病(DD)是一种常染色体显性遗传性基因皮肤病,常被漏诊或误诊。在大多数病例中,该病在青少年或年轻成人中表现为身体多个脂溢部位出现小的棕黄色、疣状、角化过度丘疹。局限性Darier病(LDD)是一种临床变异型,于1906年由Kreibich首次描述;文献中仅报道了少数病例。我们描述了一例患有LDD的老年女性病例,并对该主题的文献进行了综述。