编码Notch受体和配体的基因在人类胸腺中发育的淋巴细胞、天然调节性T细胞和树突状细胞中的组成性表达。
Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.
作者信息
Bento-de-Souza Luciana, Victor Jefferson R, Bento-de-Souza Luiz C, Arrais-Santos Magaly, Rangel-Santos Andréia C, Pereira-Costa Érica, Raniero-Fernandes Elaine, Seixas-Duarte Maria I, Oliveira-Filho João B, Silva Duarte Alberto J
机构信息
Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil; Laboratory of Pathology of Transmissible Diseases, School of Medicine - USP, São Paulo, Brazil.
Laboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
出版信息
Results Immunol. 2016 Apr 5;6:15-20. doi: 10.1016/j.rinim.2016.04.001. eCollection 2016.
The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
胸腺是T细胞成熟的场所。Notch受体（Notch1 - 4）和配体（DLL1 - 3及Jagged1 - 2）构成了参与这一过程的多条途径之一。我们的数据揭示了Notch基因和配体在T淋巴细胞和胸腺树突状细胞（tDCs）中的组成性表达存在差异，提示它们参与人类胸腺细胞的成熟。天然调节性T细胞（nTreg）分析表明，Notch组分在胸腺中平行发挥作用以促进成熟。
Zotero 插件