Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Alborz, Iran.
Nanotechnology. 2016 Sep 16;27(37):375503. doi: 10.1088/0957-4484/27/37/375503. Epub 2016 Aug 9.
In this work, a rapid and simple colorimetric method based on the surface plasmon resonance of silver nanoparticles (AgNPs) was developed for the detection of the drug Timolol. The method used is based on the interaction of Timolol with the surface of the as-synthesized AgNPs, which promotes aggregation of the nanoparticles. This aggregation exploits the surface plasmon resonance through the electric dipole-dipole interaction and coupling among the agglomerated particles, hence bringing forth distinctive changes in the spectra as well as the color of colloidal silver. UV-vis spectrophotometery was used to monitor the changes of the localized surface plasmon resonance of AgNPs at wavelengths of 400 and 550 nm. The developed colorimetric sensor has a wide dynamic range of 1.0 × 10(-7) M-1.0 × 10(-3) M for detection of Timolol with a low detection limit of 1.2 × 10(-6) M. The proposed method was successfully applied for the determination of Timolol concentration in ophthalmic eye-drop solution with a response time lower than 40 s.
在这项工作中，开发了一种基于银纳米粒子（AgNPs）表面等离子体共振的快速简单的比色法，用于检测药物噻吗洛尔。该方法基于噻吗洛尔与合成的 AgNPs 表面的相互作用，促进了纳米粒子的聚集。这种聚集通过电偶极-偶极相互作用和聚集颗粒之间的耦合利用表面等离子体共振，从而在光谱以及胶体银的颜色上产生明显的变化。紫外-可见分光光度法用于监测在 400 和 550nm 波长处 AgNPs 的局部表面等离子体共振的变化。所开发的比色传感器具有用于检测噻吗洛尔的宽动态范围为 1.0×10(-7) M-1.0×10(-3) M，检测限低至 1.2×10(-6) M。该方法成功地应用于眼用滴眼剂中噻吗洛尔浓度的测定，响应时间低于 40s。
