Favre A
LaboratoriVevy, Genova, Italia.
Acta Anat (Basel). 1989;135(1):71-6. doi: 10.1159/000146725.
The Hassall's corpuscles of man and other mammals have been deeply stained by a histochemical method that demonstrates bound histidine. We have employed a polyclonal anti-filaggrin antibody on thymus sections to verify whether this positivity was due to filaggrin and profilaggrin, its polymeric precursor, like in the skin. The immunohistochemical reaction has confirmed the presence of filaggrin in human Hassall's corpuscles as well as in other species. Different patterns have been obtained for corpuscles at different developmental stages.
人类和其他哺乳动物的哈氏小体已通过一种能显示结合组氨酸的组织化学方法被深度染色。我们在胸腺切片上使用了一种多克隆抗丝聚合蛋白抗体，以验证这种阳性反应是否像在皮肤中一样，是由丝聚合蛋白及其聚合前体前丝聚合蛋白引起的。免疫组织化学反应已证实人类哈氏小体以及其他物种中存在丝聚合蛋白。对于不同发育阶段的小体，已获得了不同的模式。
