Rossi M L, Jones N R, Candy E, Nicoll J A, Compton J S, Hughes J T, Esiri M M, Moss T H, Cruz-Sanchez F F, Coakham H B
Department of Neuropathology, Radcliffe Infirmary, Oxford, Great Britain.
Acta Neuropathol. 1989;78(2):189-93. doi: 10.1007/BF00688208.
Frozen samples from 92 malignant astrocytomas were stained with a panel of monoclonal antibodies directed against macrophages and lymphocytes. A follow-up to death was available on 68 cases which form the basis of this study. Large numbers of macrophages were found in all cases; T lymphocytes, mostly of the CD8 phenotype were also seen in moderate numbers in 70% of cases. CD4-positive cells were present in small numbers in 32% and B cells were seen in only 8% of cases. Analysis of the survival showed no demonstrable correlation between the numbers of macrophages or CD4 lymphocytes and survival. The survival curves for parenchymal CD8 infiltration diverged after 9 months suggesting increased survival for those patients without such an infiltration but the difference failed to reach statistical significance (P = 0.37). No correlation between lymphocytic cuffing and survival was seen after studying all paraffin-embedded material. We conclude that there is no significant statistical correlation between survival and the various types of mononuclear cell infiltrating malignant astrocytomas.
取自92例恶性星形细胞瘤的冷冻样本，用一组针对巨噬细胞和淋巴细胞的单克隆抗体进行染色。本研究基于68例有随访直至死亡情况的病例。所有病例中均发现大量巨噬细胞；70%的病例中也可见中等数量的T淋巴细胞，主要为CD8表型。32%的病例中有少量CD4阳性细胞，仅8%的病例中可见B细胞。生存分析显示，巨噬细胞或CD4淋巴细胞数量与生存之间无明显相关性。实质内CD8浸润的生存曲线在9个月后出现分歧，提示无此类浸润的患者生存期延长，但差异未达到统计学显著性（P = 0.37）。研究所有石蜡包埋材料后，未发现淋巴细胞套袖与生存之间存在相关性。我们得出结论，生存与浸润恶性星形细胞瘤的各类单核细胞之间无显著统计学相关性。
