Mantovani Rafael Machado, Rocha Natália Pessoa, Magalhães Daniel Massote, Barbosa Izabela Guimarães, Teixeira Antônio Lúcio, Simões E Silva Ana Cristina
Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte, MG, Brazil.
J Pediatr (Rio J). 2016 Nov-Dec;92(6):624-630. doi: 10.1016/j.jped.2016.02.015. Epub 2016 Aug 7.
Childhood obesity has been associated with metabolic syndrome and cardiovascular diseases. This study aimed to compare plasma levels of traditional metabolic markers, adipokines and soluble tumor necrosis factor receptor type 1 (sTNFR1) in overweight, obese and lean children. We also assessed the relationships of these molecules with classical metabolic risk factors.
This study included 104 children and adolescents, which were grouped as: lean (n=24), overweight (n=30), and obese subjects (n=50). They were subjected to anthropometrical, clinical and laboratorial measurements. All measurements were compared between groups. Correlation analyses were also performed to evaluate the association between clinical data, traditional metabolic markers, adipokines and sTNFR1.
Fasting glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), LDL-cholesterol and triglycerides were comparable in lean, overweight and obese subjects. Plasma levels of sTNFR1 were similar in lean and overweight subjects, but significantly increased in obese group. Leptin, adiponectin and resistin levels did not differ when overweight were compared to obese subjects. However, all adipokines differed significantly when lean subjects were compared to overweight and obese individuals. Plasma levels of adiponectin were negatively correlated with body mass index (BMI), whereas leptin, resistin and sTNFR1 concentrations positively correlated with BMI.
Our results showed significant differences in circulating levels of the evaluated markers when lean, overweight and obese individuals were compared, suggesting that these biomarkers may change from lean to overweight and from overweight to obesity.
儿童肥胖与代谢综合征及心血管疾病有关。本研究旨在比较超重、肥胖和消瘦儿童血浆中传统代谢标志物、脂肪因子和可溶性肿瘤坏死因子受体1（sTNFR1）的水平。我们还评估了这些分子与经典代谢危险因素之间的关系。
本研究纳入104名儿童和青少年，分为：消瘦组（n = 24）、超重组（n = 30）和肥胖组（n = 50）。对他们进行人体测量、临床和实验室检测。比较各组间的所有检测结果。还进行了相关性分析，以评估临床数据、传统代谢标志物、脂肪因子和sTNFR1之间的关联。
消瘦、超重和肥胖受试者的空腹血糖、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、低密度脂蛋白胆固醇和甘油三酯水平相当。消瘦和超重组受试者的血浆sTNFR1水平相似，但肥胖组显著升高。超重与肥胖受试者相比，瘦素、脂联素和抵抗素水平无差异。然而，消瘦受试者与超重和肥胖个体相比，所有脂肪因子均有显著差异。血浆脂联素水平与体重指数（BMI）呈负相关，而瘦素、抵抗素和sTNFR1浓度与BMI呈正相关。
我们的结果显示，比较消瘦、超重和肥胖个体时，所评估标志物的循环水平存在显著差异，表明这些生物标志物可能会随着从消瘦到超重以及从超重到肥胖的转变而发生变化。
