默认模式网络（DMN）在神经和神经精神疾病中的意义：综述
The Significance of the Default Mode Network (DMN) in Neurological and Neuropsychiatric Disorders: A Review.
作者信息
Mohan Akansha, Roberto Aaron J, Mohan Abhishek, Lorenzo Aileen, Jones Kathryn, Carney Martin J, Liogier-Weyback Luis, Hwang Soonjo, Lapidus Kyle A B
机构信息
Baylor College of Medicine, Houston, Texas.
Clinical fellow, Child and Adolescent Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
出版信息
Yale J Biol Med. 2016 Mar 24;89(1):49-57. eCollection 2016 Mar.
Abstract
The relationship of cortical structure and specific neuronal circuitry to global brain function, particularly its perturbations related to the development and progression of neuropathology, is an area of great interest in neurobehavioral science. Disruption of these neural networks can be associated with a wide range of neurological and neuropsychiatric disorders. Herein we review activity of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease, Epilepsy (Temporal Lobe Epilepsy - TLE), attention deficit hyperactivity disorder (ADHD), and mood disorders. We discuss the implications of DMN disruptions and their relationship to the neurocognitive model of each disease entity, the utility of DMN assessment in clinical evaluation, and the changes of the DMN following treatment.
摘要
皮质结构和特定神经元回路与全脑功能的关系，尤其是其与神经病理学发展和进展相关的扰动，是神经行为科学中一个备受关注的领域。这些神经网络的破坏可能与多种神经和神经精神疾病有关。在此，我们综述了默认模式网络（DMN）在神经和神经精神疾病中的活动，包括阿尔茨海默病、帕金森病、癫痫（颞叶癫痫 - TLE）、注意力缺陷多动障碍（ADHD）和情绪障碍。我们讨论了DMN破坏的影响及其与每种疾病实体的神经认知模型的关系、DMN评估在临床评估中的效用以及治疗后DMN的变化。
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