Merriam G R, Ma N, Liu L, Wachter K W, Libre E
Reproductive Endocrine Unit, National Institute of Child Health and Human Development, Bethesda, Maryland.
Acta Paediatr Scand Suppl. 1989;349:167-72. doi: 10.1111/j.1651-2227.1989.tb17217.x.
Although the different anterior pituitary hormones are generally considered to be regulated independently, examination of their patterns in blood suggests that pulsatile secretion of several of these hormones may be synchronized. Traditional methods of cross-correlation analysis may not be adequate for quantifying this linkage. Since some simultaneity may arise by chance, expected rates of random coincidences must also be estimated to determine if apparent concordance rates significantly exceed those due to chance. A method of estimating linkage by counting simultaneous and near-simultaneous events within temporal 'windows' of varying width is proposed and tested against 11 series of luteinizing hormone (LH) and prolactin measurements from normal men. Rates of concordance in series drawn from different subjects rather than the same subject, or series scrambled in time, do not contain meaningful simultaneous events and so can be used to estimate the rate of random synchrony. By these standards, a clear excess of concordant prolactin and luteinizing hormone (LH) peaks was observed in normal men, suggesting significant physiological synchrony between these pulses of secretion. This method can be applied to a variety of hormonal systems.
虽然通常认为垂体前叶分泌的不同激素是独立调节的，但对其血液中的分泌模式进行检查发现，其中几种激素的脉冲式分泌可能是同步的。传统的互相关分析方法可能不足以量化这种联系。由于某些同时发生的情况可能是偶然出现的，因此还必须估计随机巧合的预期发生率，以确定明显的一致率是否显著超过偶然因素导致的一致率。本文提出了一种通过计算不同宽度时间“窗口”内同时发生和几乎同时发生的事件来估计联系的方法，并针对来自正常男性的11组促黄体生成素（LH）和催乳素测量数据进行了测试。从不同受试者而非同一受试者获取的系列数据，或时间上打乱顺序的系列数据中的一致率，不包含有意义的同时发生事件，因此可用于估计随机同步率。按照这些标准，在正常男性中观察到催乳素和促黄体生成素（LH）峰值明显过多的一致情况，这表明这些分泌脉冲之间存在显著的生理同步。该方法可应用于多种激素系统。
