Atalabi Omolola Mojisola, Afolabi Oluniyi S, Asinobi Adanze O
Department of Radiology, College of Medicine, University of Ibadan /University College Hospital, Ibadan.
Niger J Physiol Sci. 2015 Dec 20;30(1-2):17-23.
The resistive and pulsatility indices are known tools for assessing renal function in kidney diseases, especially in proteinuric conditions like Paediatric Nephrotic syndrome (NS) which is a glomerular disease. However, there is a limited knowledge in the use of Doppler Resistive and pulsatility indices in the management of this disease condition. This was a case control study involving 53 cases and 57 controls. The Doppler parameters, resistive index (RI) and pulsatility index (PI) of the renal interlobar arteries were determined for the upper, middle, and lower poles bilaterally for both controls and cases. The mean RI on the right and left were 0.59 ± 0.06 and 0.58 ± 0.06 respectively for the NS cases whereas for the controls it was 0.61 ± 0.05 and 0.60 ± 0.04 on the right and left respectively. The mean PI on the right and left measured 0.96 ± 0.16 and 0.94 ± 0.15 respectively for the NS cases while that for the control cases measured 0.98 ± 0.13.and 0.95 ± 0.12 on the right and left respectively. Although, the interlobar arteries mean RIs were generally less than that for the controls, but only the left middle pole showed statistically significant mean difference (p= 0.004). There was also statistically significant mean difference (p= 0.048) between the cases and controls in the left middle pole PI. However, no correlation was found when the renal RI and PI are compared with the serum albumin and creatinine. Although there was no statistical significance between the mean RI and PI of the NS cases and controls, except in the left middle pole RI, it is recommended that Doppler ultrasound should still be part of management of Nephrotic syndrome patients especially those who have developed end stage renal disease in order to monitor their renal function.
阻力指数和搏动指数是评估肾脏疾病肾功能的常用工具，尤其是在诸如小儿肾病综合征（NS）这种肾小球疾病的蛋白尿情况下。然而，在该疾病的管理中使用多普勒阻力指数和搏动指数的相关知识有限。这是一项病例对照研究，涉及53例病例和57例对照。对对照组和病例组双侧肾脏上、中、下极的肾叶间动脉的多普勒参数，即阻力指数（RI）和搏动指数（PI）进行了测定。NS病例组右侧和左侧的平均RI分别为0.59±0.06和0.58±0.06，而对照组右侧和左侧分别为0.61±0.05和0.60±0.04。NS病例组右侧和左侧的平均PI分别为0.96±0.16和0.94±0.15，而对照组右侧和左侧分别为0.98±0.13和0.95±0.12。虽然，肾叶间动脉的平均RI总体上低于对照组，但仅左中极显示出统计学上的显著平均差异（p = 0.004）。病例组和对照组在左中极PI方面也存在统计学上的显著平均差异（p = 0.048）。然而，当将肾脏RI和PI与血清白蛋白和肌酐进行比较时，未发现相关性。虽然NS病例组和对照组的平均RI和PI之间除了左中极RI外没有统计学意义，但建议多普勒超声仍应作为肾病综合征患者管理的一部分，尤其是那些已发展为终末期肾病的患者，以便监测他们的肾功能。
