Smith D K, Feldman E B, Feldman D S
Department of Medicine, Medical College of Georgia, Augusta 30912.
Am J Clin Nutr. 1989 Jul;50(1):136-40. doi: 10.1093/ajcn/50.1.136.
We compared trace element status in multiple sclerosis (MS) patients (n = 27) with and without treatment with corticosteroids and groups of healthy subjects. Concentrations of plasma ceruloplasmin, selenium, and zinc and erythrocyte (RBC) glutathione peroxidase, Se, and Zn were similar in all groups. RBC copper concentrations were significantly lower in MS patients than in control subjects (mean +/- SEM: 0.048 +/- 0.005 vs 0.060 +/- 0.002 mumol/g Hb) because of decreased RBC Cu with steroid therapy. RBC Zn-Cu ratios were significantly higher (14.9 +/- 1.0 vs 10.1 +/- 0.3) in MS patients than in control subjects, differing in both groups of MS patients. In MS and control subjects, RBC Cu correlated significantly with RBC Zn (r = 0.56, 0.49). Disease acuity and disability had no effect on trace-mineral status. These data suggest that in MS there is altered Cu and Zn homeostasis that may cause or result from the disease and is influenced by corticosteroid therapy. Systemic trace element alterations might provide clinically useful markers of MS.
我们比较了接受和未接受皮质类固醇治疗的多发性硬化症（MS）患者（n = 27）以及健康受试者组的微量元素状况。所有组中血浆铜蓝蛋白、硒和锌的浓度以及红细胞（RBC）谷胱甘肽过氧化物酶、硒和锌的浓度相似。由于类固醇治疗导致红细胞铜含量降低，MS患者的红细胞铜浓度显著低于对照组（平均值±标准误：0.048±0.005 vs 0.060±0.002 μmol/g Hb）。MS患者的红细胞锌铜比显著高于对照组（14.9±1.0 vs 10.1±0.3），两组MS患者之间存在差异。在MS患者和对照组中，红细胞铜与红细胞锌显著相关（r = 0.56，0.49）。疾病的严重程度和残疾程度对微量矿物质状况没有影响。这些数据表明，在MS中，铜和锌的体内稳态发生了改变，这可能是由疾病引起的，也可能导致疾病，并且受到皮质类固醇治疗的影响。全身微量元素的改变可能为MS提供临床上有用的标志物。
