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本文引用的文献

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Opioid overdose prevention through pharmacy-based naloxone prescription program: Innovations in health care delivery.通过基于药房的纳洛酮处方计划预防阿片类药物过量:医疗服务提供方面的创新。
Subst Abus. 2017 Jan-Mar;38(1):55-60. doi: 10.1080/08897077.2016.1184739. Epub 2016 May 10.
2
Increases in Drug and Opioid Overdose Deaths--United States, 2000-2014.药物和阿片类药物过量死亡人数增加 - 美国,2000-2014 年。
MMWR Morb Mortal Wkly Rep. 2016 Jan 1;64(50-51):1378-82. doi: 10.15585/mmwr.mm6450a3.
3
Use of Naloxone by Emergency Medical Services during Opioid Drug Overdose Resuscitation Efforts.紧急医疗服务在阿片类药物过量复苏过程中使用纳洛酮的情况。
Prehosp Emerg Care. 2016;20(2):220-5. doi: 10.3109/10903127.2015.1076096. Epub 2015 Sep 18.
4
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J Urban Health. 2015 Aug;92(4):758-72. doi: 10.1007/s11524-015-9967-y.
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Disparity in naloxone administration by emergency medical service providers and the burden of drug overdose in US rural communities.美国农村社区紧急医疗服务提供者在纳洛酮使用上的差异与药物过量负担
Am J Public Health. 2015 Jul;105 Suppl 3(Suppl 3):e26-32. doi: 10.2105/AJPH.2014.302520. Epub 2015 Apr 23.
6
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Vital signs: overdoses of prescription opioid pain relievers and other drugs among women--United States, 1999-2010.生命体征:1999-2010 年美国女性处方类阿片类止痛药和其他药物过量情况。
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2012年新墨西哥州对阿片类药物过量致死事件的认识与应对

Recognition and response to opioid overdose deaths-New Mexico, 2012.

作者信息

Levy Benjamin, Spelke Bridget, Paulozzi Leonard J, Bell Jeneita M, Nolte Kurt B, Lathrop Sarah, Sugerman David E, Landen Michael

机构信息

Division of Unintentional Injury Prevention, Centers for Disease Control and Prevention, 4770 Buford Highway MS-F62, Chamblee, GA 30341, United States.

Women and Infants' Hospital of Rhode Island, Warrren Alpert Medical School at Brown University, United States.

出版信息

Drug Alcohol Depend. 2016 Oct 1;167:29-35. doi: 10.1016/j.drugalcdep.2016.07.011. Epub 2016 Aug 3.

DOI:10.1016/j.drugalcdep.2016.07.011
PMID:27507658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6018001/
Abstract

PURPOSE

Drug overdose deaths are epidemic in the U.S. Prescription opioid pain relievers (OPR) and heroin account for the majority of drug overdoses. Preventing death after an opioid overdose by naloxone administration requires the rapid identification of the overdose by witnesses. This study used a state medical examiner database to characterize fatal overdoses, evaluate witness-reported signs of overdose, and identify opportunities for intervention.

METHODS

We reviewed all unintentional drug overdose deaths that occurred in New Mexico during 2012. Data were abstracted from medical examiner records at the New Mexico Office of the Medical Investigator. We compared mutually exclusive groups of OPR and heroin-related deaths.

RESULTS

Of the 489 overdose deaths reviewed, 49.3% involved OPR, 21.7% involved heroin, 4.7% involved a mixture of OPR and heroin, and 24.3% involved only non-opioid substances. The majority of OPR-related deaths occurred in non-Hispanic whites (57.3%), men (58.5%), persons aged 40-59 years (55.2%), and those with chronic medical conditions (89.2%). Most overdose deaths occurred in the home (68.7%) and in the presence of bystanders (67.7%). OPR and heroin deaths did not differ with respect to paramedic dispatch and CPR delivery, however, heroin overdoses received naloxone twice as often (20.8% heroin vs. 10.0% OPR; p<0.01).

CONCLUSION

OPR overdose deaths differed by age, health status, and the presence of bystanders, yet received naloxone less often when compared to heroin overdose deaths. These findings suggest that naloxone education and distribution should be targeted in future prevention efforts.

摘要

目的

药物过量致死在美国呈流行态势。处方阿片类镇痛药(OPR)和海洛因导致了大多数药物过量死亡案例。通过使用纳洛酮来预防阿片类药物过量后的死亡,需要目击者迅速识别出药物过量情况。本研究利用一个州法医数据库来描述致命药物过量案例的特征,评估目击者报告的药物过量迹象,并确定干预机会。

方法

我们回顾了2012年在新墨西哥州发生的所有非故意药物过量死亡案例。数据从新墨西哥州医学调查员办公室的法医记录中提取。我们比较了OPR相关死亡案例和海洛因相关死亡案例这两个相互排斥的组。

结果

在审查的489例药物过量死亡案例中,49.3%涉及OPR,21.7%涉及海洛因,4.7%涉及OPR和海洛因的混合物,24.3%仅涉及非阿片类物质。大多数与OPR相关的死亡发生在非西班牙裔白人(57.3%)、男性(58.5%)、40 - 59岁的人群(55.2%)以及患有慢性疾病的人群(89.2%)中。大多数药物过量死亡发生在家中(68.7%)且有旁观者在场(67.7%)。在护理人员派遣和心肺复苏实施方面,OPR和海洛因导致的死亡没有差异,然而,海洛因过量案例接受纳洛酮治疗的频率是OPR过量案例的两倍(海洛因为20.8%,OPR为10.0%;p<0.01)。

结论

OPR过量死亡在年龄、健康状况和旁观者在场情况方面存在差异,但与海洛因过量死亡相比,接受纳洛酮治疗的频率较低。这些发现表明,在未来的预防工作中,应针对纳洛酮进行教育和推广。