Levy Benjamin, Spelke Bridget, Paulozzi Leonard J, Bell Jeneita M, Nolte Kurt B, Lathrop Sarah, Sugerman David E, Landen Michael
Division of Unintentional Injury Prevention, Centers for Disease Control and Prevention, 4770 Buford Highway MS-F62, Chamblee, GA 30341, United States.
Women and Infants' Hospital of Rhode Island, Warrren Alpert Medical School at Brown University, United States.
Drug Alcohol Depend. 2016 Oct 1;167:29-35. doi: 10.1016/j.drugalcdep.2016.07.011. Epub 2016 Aug 3.
Drug overdose deaths are epidemic in the U.S. Prescription opioid pain relievers (OPR) and heroin account for the majority of drug overdoses. Preventing death after an opioid overdose by naloxone administration requires the rapid identification of the overdose by witnesses. This study used a state medical examiner database to characterize fatal overdoses, evaluate witness-reported signs of overdose, and identify opportunities for intervention.
We reviewed all unintentional drug overdose deaths that occurred in New Mexico during 2012. Data were abstracted from medical examiner records at the New Mexico Office of the Medical Investigator. We compared mutually exclusive groups of OPR and heroin-related deaths.
Of the 489 overdose deaths reviewed, 49.3% involved OPR, 21.7% involved heroin, 4.7% involved a mixture of OPR and heroin, and 24.3% involved only non-opioid substances. The majority of OPR-related deaths occurred in non-Hispanic whites (57.3%), men (58.5%), persons aged 40-59 years (55.2%), and those with chronic medical conditions (89.2%). Most overdose deaths occurred in the home (68.7%) and in the presence of bystanders (67.7%). OPR and heroin deaths did not differ with respect to paramedic dispatch and CPR delivery, however, heroin overdoses received naloxone twice as often (20.8% heroin vs. 10.0% OPR; p<0.01).
OPR overdose deaths differed by age, health status, and the presence of bystanders, yet received naloxone less often when compared to heroin overdose deaths. These findings suggest that naloxone education and distribution should be targeted in future prevention efforts.
药物过量致死在美国呈流行态势。处方阿片类镇痛药(OPR)和海洛因导致了大多数药物过量死亡案例。通过使用纳洛酮来预防阿片类药物过量后的死亡,需要目击者迅速识别出药物过量情况。本研究利用一个州法医数据库来描述致命药物过量案例的特征,评估目击者报告的药物过量迹象,并确定干预机会。
我们回顾了2012年在新墨西哥州发生的所有非故意药物过量死亡案例。数据从新墨西哥州医学调查员办公室的法医记录中提取。我们比较了OPR相关死亡案例和海洛因相关死亡案例这两个相互排斥的组。
在审查的489例药物过量死亡案例中,49.3%涉及OPR,21.7%涉及海洛因,4.7%涉及OPR和海洛因的混合物,24.3%仅涉及非阿片类物质。大多数与OPR相关的死亡发生在非西班牙裔白人(57.3%)、男性(58.5%)、40 - 59岁的人群(55.2%)以及患有慢性疾病的人群(89.2%)中。大多数药物过量死亡发生在家中(68.7%)且有旁观者在场(67.7%)。在护理人员派遣和心肺复苏实施方面,OPR和海洛因导致的死亡没有差异,然而,海洛因过量案例接受纳洛酮治疗的频率是OPR过量案例的两倍(海洛因为20.8%,OPR为10.0%;p<0.01)。
OPR过量死亡在年龄、健康状况和旁观者在场情况方面存在差异,但与海洛因过量死亡相比,接受纳洛酮治疗的频率较低。这些发现表明,在未来的预防工作中,应针对纳洛酮进行教育和推广。