大麻素作为化疗引起的恶心和呕吐的潜在治疗方法。
Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting.
作者信息
Rock Erin M, Parker Linda A
机构信息
Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph Guelph, ON, Canada.
出版信息
Front Pharmacol. 2016 Jul 26;7:221. doi: 10.3389/fphar.2016.00221. eCollection 2016.
Abstract
Despite the advent of classic anti-emetics, chemotherapy-induced nausea is still problematic, with vomiting being somewhat better managed in the clinic. If post-treatment nausea and vomiting are not properly controlled, anticipatory nausea-a conditioned response to the contextual cues associated with illness-inducing chemotherapy-can develop. Once it develops, anticipatory nausea is refractive to current anti-emetics, highlighting the need for alternative treatment options. One of the first documented medicinal uses of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) was for the treatment of chemotherapy-induced nausea and vomiting (CINV), and recent evidence is accumulating to suggest a role for the endocannabinoid system in modulating CINV. Here, we review studies assessing the therapeutic potential of cannabinoids and manipulations of the endocannabinoid system in human patients and pre-clinical animal models of nausea and vomiting.
摘要
尽管经典止吐药已经问世，但化疗引起的恶心仍然是个问题，在临床上呕吐的控制情况相对较好。如果治疗后恶心和呕吐没有得到妥善控制，就可能会出现预期性恶心——这是一种对与引发疾病的化疗相关的情境线索的条件反应。一旦出现，预期性恶心对目前的止吐药具有抗性，这凸显了需要其他治疗选择。Δ(9)-四氢大麻酚（Δ(9)-THC）最早记录的药用之一就是治疗化疗引起的恶心和呕吐（CINV），最近越来越多的证据表明内源性大麻素系统在调节CINV中发挥作用。在此，我们综述了评估大麻素的治疗潜力以及在人类患者和恶心呕吐的临床前动物模型中对内源性大麻素系统进行调控的研究。
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