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用于构建和利用AlloRep数据库的出版物、结构分析及查询数据。

Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.

作者信息

Sousa Filipa L, Parente Daniel J, Hessman Jacob A, Chazelle Allen, Teichmann Sarah A, Swint-Kruse Liskin

机构信息

Institute of Molecular Evolution, Heinrich-Heine Universität Düsseldorf, Universitätstrasse 1, 40225 Düsseldorf, Germany.

The Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

出版信息

Data Brief. 2016 Jul 9;8:948-57. doi: 10.1016/j.dib.2016.07.006. eCollection 2016 Sep.

Abstract

The AlloRep database (www.AlloRep.org) (Sousa et al., 2016) [1] compiles extensive sequence, mutagenesis, and structural information for the LacI/GalR family of transcription regulators. Sequence alignments are presented for >3000 proteins in 45 paralog subfamilies and as a subsampled alignment of the whole family. Phenotypic and biochemical data on almost 6000 mutants have been compiled from an exhaustive search of the literature; citations for these data are included herein. These data include information about oligomerization state, stability, DNA binding and allosteric regulation. Protein structural data for 65 proteins are presented as easily-accessible, residue-contact networks. Finally, this article includes example queries to enable the use of the AlloRep database. See the related article, "AlloRep: a repository of sequence, structural and mutagenesis data for the LacI/GalR transcription regulators" (Sousa et al., 2016) [1].

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ce9/4961497/0a66308f89fe/gr1.jpg

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