慢性阻塞性肺疾病的体外支持：光明未来。

Extracorporeal Support for Chronic Obstructive Pulmonary Disease: A Bright Future.

作者信息

Trahanas John M, Lynch William R, Bartlett Robert H

机构信息

1 Department of Surgery, Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI, USA.

2 Department of Surgery, Section of General Surgery, Columbia University Medical Center, New York, NY, USA.

出版信息

J Intensive Care Med. 2017 Aug;32(7):411-420. doi: 10.1177/0885066616663119. Epub 2016 Aug 10.

DOI:10.1177/0885066616663119

PMID:27509917

Abstract

In the past the only option for the treatment of respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease (aeCOPD) was invasive mechanical ventilation. In recent decades, the potential for extracorporeal carbon dioxide (CO) removal has been realized. We review the various types of extracorporeal CO removal, outline the optimal use of these therapies for aeCOPD, and make suggestions for future controlled trials. We also describe the advantages and requirements for an ideal long-term ambulatory CO removal system for palliation of COPD.

摘要

过去，慢性阻塞性肺疾病急性加重（aeCOPD）所致呼吸衰竭的唯一治疗选择是有创机械通气。近几十年来，体外二氧化碳（CO）清除的潜力已得到认识。我们回顾了各种类型的体外CO清除方法，概述了这些疗法在aeCOPD中的最佳应用，并对未来的对照试验提出建议。我们还描述了用于缓解COPD的理想长期门诊CO清除系统的优点和要求。